{"id":1809,"date":"2018-01-10T14:55:24","date_gmt":"2018-01-10T11:55:24","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=1809"},"modified":"2018-02-14T15:50:53","modified_gmt":"2018-02-14T12:50:53","slug":"2016-1-9","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2016-1-9\/","title":{"rendered":"2016 (1) 9"},"content":{"rendered":"<p><a href=\"https:\/\/doi.org\/10.15407\/polymerj.38.01.066\">https:\/\/doi.org\/10.15407\/polymerj.38.01.066<\/a><\/p>\n<p><strong>Micellar compositions with doxorubicin and their cytotoxicity<\/strong><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<p><strong><em>L.R. Kunitskaya<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, <\/em><\/strong><strong><em>\u0422<\/em><\/strong><strong><em>.B. Zheltonozhskaya<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>,<\/em><\/strong> <strong><em>R.S. Stoik<\/em><\/strong><strong><em>\u0430<\/em><\/strong><strong><em>2<\/em><\/strong><strong><em>, N.<\/em><\/strong><strong><em>\u041c<\/em><\/strong><strong><em>. Boiko<\/em><\/strong><strong><em>2<\/em><\/strong><strong><em>\u00a0<\/em><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>1Kiev Taras Shevchenko National University<\/p>\n<p>60 Vladimirskaya Str., 01033, Kiev, Ukraine<\/p>\n<p>2Institute of Cell Biology NAS of Ukraine<\/p>\n<p>14\/6 Dragomanova Str., 79005 Lviv, Ukraine<\/p>\n<p>&nbsp;<\/p>\n<p>Polym. J., 2016, <strong>38<\/strong>, no. 1: 66-75.<\/p>\n<p>&nbsp;<\/p>\n<p>Section: Medical polymers.<\/p>\n<p>&nbsp;<\/p>\n<p>Language: Ukrainian.<\/p>\n<p>&nbsp;<\/p>\n<p>Abstract:<\/p>\n<p><em>The micellar compositions with doxorubicin, in which the carriers of toxic anticancer drug are micelles of diblock- and triblock copolymers (DBC and TBC) containing asymmetric chemically complementary (methoxy)polyethylenoxide and polyacrylamide (MOPEO-b-PAAm and PAAm-b-PEO-b-PAAm) and also partially hydrolyzed triblock copolymer\u2019s derivative (TBC-COOH) were investigated. It is shown, that both initial and hydrolyzed block copolymers form special micelles of mono- and polymolecular type in aqueous medium. Such micelles have small CMC due to the intramolecular interaction of chemically complementary blocks. It has been found that micellar compositions of TBC and\u00a0 TBC-COOH with anticancer agent doxorubicin increase the cellulotoxic action of the drug and allowed to reduce its general toxicity due to the lowering of the therapeutic dose when used in chemotherapy.<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Key words: <\/strong>polyethylene glycol, polyacrylamide, micellar compositions, anticancer drugs.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u041b\u0456\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u0430<\/strong><\/p>\n<p>1. \u0424\u043e\u0440\u0441\u0442\u0435\u0440 \u041b. \u041d\u0430\u043d\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438. \u041d\u0430\u0443\u043a\u0430, \u0438\u043d\u043d\u043e\u0432\u0430\u0446\u0438\u0438 \u0438 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438. \u2013 \u0422\u0435\u0445\u043d\u043e\u0441\u0444\u0435\u0440\u0430, 2014.- 2461 \u0441.<br \/>\n2. Torchilin V.P.(Ed.) Nanoparticulates as drug carriers. \u2013 London: Imperial College Press, 2006 \u2013 754 p.<br \/>\n3. Tong R., Cheng J. Anticancer polymeric nanomedicines \/\/ Polym. Rev. \u2013 2007. \u2013 47. \u2013 P.345-381.<br \/>\n4. Attia A.B.E., Ong Z.Y., Hedrick J.L., Lee P.P., Ee P.L.R., Hammond P.T., Yang Y.-Y. Mixed micelles self-assembled from block copolymers for drug delivery \/\/ Curr. Opin. Coll. Int. Sci.\u2013 2011.\u201316, P.182-194.<br \/>\n5. Osada K., Christie R.J., Kataoka K. Polymeric micelles from poly(ethylene glycol)-poly(amine acid) block copolymer for drug and gene delivery \/\/ J. Royal Soc. Inerface. \u2013 2009.\u2013 6. \u2013 P. S325-S339.<br \/>\n6. Dane K.Y., Nembrini C., Tomei A.A., Eby J.K., O\u2019Neil C.P., Velluto D., Swartz M.A., Inverardi L., Hubbell J.A. Nano-sized drug-loaded micelles deliver payload to lymph node immune cells and prolong allograft survival \/\/ J. Contr. Release \u2013 2011. \u2013 156. \u2013 P.154-160.<br \/>\n7. Zhang Q., Ko N.R., Oh J.K. Recent advances in stimuli-responsive degradable block copolymer micelles: synthesis and controlled drug delivery \/\/ Chem. Commun. \u2013 2012. \u2013 48. \u2013 P. 7542-7552.<br \/>\n8. Freichels H., Jerome R., Jerome C. Sugar-labeled and PEGylated (bio)degradable polymers intended for targeted drug delivery systems \/\/ Carbohydrate Polym. \u2013 2011. \u2013 86. \u2013 P. 1093-1106.<br \/>\n9. \u041c\u0430\u0442\u044f\u0448 \u041c., \u041a\u0440\u0430\u0432\u0447\u0443\u043a \u0422., \u0412\u044b\u0441\u043e\u0446\u043a\u0430\u044f \u0412., \u0427\u0435\u0440\u043d\u043e\u0432 \u0412., \u0413\u043e\u043b\u044c\u0434\u0431\u0435\u0440\u0433 \u0412. \u0418\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u0430\u044f \u0430\u043d\u0442\u0440\u0430\u0446\u0438\u043a\u043b\u0438\u043d\u0430\u043c\u0438 \u043a\u0430\u0440\u0434\u0438\u043e\u0442\u043e\u043a\u0441\u0438\u0447\u043d\u043e\u0441\u0442\u044c: \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u044b \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u043e\u044f\u0432\u043b\u0435\u043d\u0438\u044f \/\/ \u0421\u0438\u0431\u0438\u0440\u0441\u043a\u0438\u0439 \u043e\u043d\u043a\u043e\u043b. \u0436\u0443\u0440\u043d. &#8211; 2008. &#8211; \u2116 6. &#8211; \u0421.66-75.<br \/>\n10. \u0421\u0430\u043c\u0443\u0440\u0430 \u0411. \u041f\u043e\u0432\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u044f \u043c\u0438\u043e\u043a\u0430\u0440\u0434\u0430, \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u0430\u043d\u0442\u0440\u0430\u0446\u0438\u043a\u043b\u0438\u043d\u0430\u043c\u0438. \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435\/\/ Therapia. &#8211; 2008. &#8211; \u211612. \u2013 \u0421. 46-52.<br \/>\n11. Sakthibalan M., Sawadkar M.S., Asmathulla S, Ivan E.A., Muthu G. Study of cardio protective effect of N-acetylcysteine, Vitamin C \/\/ J. Pharm. Biomed. Sci. \u2013 2013. \u2013 36. \u2013 P. 1902-1908.<br \/>\n12. Noh T., Kook Y.H., Park C., Youn H., Kim H., Oh E.T., Choi E.K., Park H.J., Kim C. Block copolymer micelles conjugated with anti-EGFR antibody for targeted delivery of anticancer drug \/\/ J. Polym. Sci.: Part A: Polym. Chem. \u2013 2008. \u2013 46. \u2013 P.7321-7331.<br \/>\n13. Glen S., Marcus L. Micelle composition of polymer and passenger drug \/\/US Patent \u2116 8,173,167.- Issued date 08.05.2012.<br \/>\n14. Xu Y., Meng F., Cheng R., Zhong Z. Reduction-sensitive reversibly crosslinked biodegradable micelles for triggered release of doxorubicin.\/\/ Macromol. Biosci. &#8211; 2009. \u2013 9. \u2013 P. 1-7.<br \/>\n15. \u0415\u0432\u0440\u0430\u0437\u0438\u0439\u0441\u043a\u0438\u0439 \u043f\u0430\u0442\u0435\u043d\u0442 017682 \u04121. \u041f\u043e\u043b\u0438\u043c\u0435\u0440 \u0438 \u0441\u043f\u043e\u0441\u043e\u0431 \u0435\u0433\u043e \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u044f, \u0444\u0430\u0440\u043c\u0430\u0446\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u043a\u043e\u043c\u043f\u043e\u0437\u0438\u0446\u0438\u044f \u0432 \u0444\u043e\u0440\u043c\u0435 \u043d\u0430\u043d\u043e\u0447\u0430\u0441\u0442\u0438\u0446, \u0441\u043f\u043e\u0441\u043e\u0431 \u0438 \u043d\u0430\u0431\u043e\u0440 \u0434\u043b\u044f \u0435\u0435 \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u044f \u0438 \u0441\u043f\u043e\u0441\u043e\u0431 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u0439 \u0443 \u043b\u044e\u0434\u0435\u0439 \u0438\u043b\u0438 \u0436\u0438\u0432\u043e\u0442\u043d\u044b\u0445. \/\/ \u0410\u043d\u0430\u043d\u0434 \u0411., \u0420\u0430\u043c\u0430 \u041c., \u0414\u0445\u0438\u0440\u0430\u0434\u0436 \u0425., \u0421\u0430\u043d\u0434\u0436\u043e\u0439 \u041c., \u041c\u0430-\u043d\u0443 \u0414., \u041a\u0443\u043c\u0430\u0440 \u0421., \u041c\u0443\u043a\u0435\u0448 \u041a., \u0414\u0438\u043f\u0430\u043a \u041f., \u041a\u0443\u043c\u0430\u0440 \u0413., \u0420\u0430\u0434\u0436\u0435\u043d\u0434\u0440\u0430\u043d \u041f., \u0428\u043e\u0431\u0445\u0438\u0442 \u0421. \u2013 \u041e\u043f\u0443\u0431\u043b. 28.02.2013.<br \/>\n16. \u041f\u0430\u0442\u0435\u043d\u0442 \u0420\u0424 2308943 \u04212. \u041a\u043e\u043c\u043f\u043e\u0437\u0438\u0446\u0438\u0438 \u043f\u043e\u043b\u0438\u043c\u0435\u0440\u043d\u044b\u0445 \u043c\u0438\u0446\u0435\u043b\u043b \/\/ \u041b\u0435\u0440\u0443 \u0416-\u041a., \u0411\u0435\u043d\u0430\u0445\u043c\u0435\u0434 \u0410.\u0421. \u2013 \u041e\u043f\u0443\u0431\u043b. 27.10.2007.<br \/>\n17. \u0414\u0437\u0443\u043d \u041c. \u041d\u043e\u0432\u044b\u0439 \u0442\u0432\u0435\u0440\u0434\u044b\u0439 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442, \u0441\u043e\u0434\u0435\u0440\u0436\u0430\u0449\u0438\u0439 \u0431\u043b\u043e\u043a-\u0441\u043e\u043f\u043e\u043b\u0438\u043c\u0435\u0440 \u0438 \u0430\u0442\u0440\u0430\u0446\u0438\u043a\u043b\u0438\u043d\u043e\u0432\u044b\u0439 \u043f\u0440\u043e\u0442\u0438\u0432\u043e\u043e\u043f\u0443\u0445\u043e\u043b\u0435\u0432\u044b\u0439 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442, \u0438 \u0441\u043f\u043e\u0441\u043e\u0431 \u0435\u0433\u043e \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u044f \/\/ \u041f\u0430\u0442\u0435\u043d\u0442 \u0420\u0424 \u2116 2321412. \u041e\u043f\u0443\u0431\u043b. 10.04.2008.<br \/>\n18. Heller G., Ng S.-Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers \/\/ US Patent No: 5,939,453.- Issued date 17.08.1999.<br \/>\n19. Kunitskaya L, Zheltonozhskaya T., Berkova S. Block-Copolymers of Polyacrylamide with Poly(Ethylene Oxide) forming Intramolecular Polycomplexes \/\/ Mol.Cryst.Liq. Cryst. \u2013 2008.\u2013 497. \u2013 P. 282-291<br \/>\n20. Zheltonozhskaya T., Nedashkovskaya V., Khutoryanskiy V., Gomza Yu., Fedorchuk S., Klepko V., Partsevskaya S. Micelles of PAAm-b-PEO-b-PAAm triblock copolymers and their binding with prednisolon\/\/ Molecular Cryst. Liquid Cryst. \u2013 2011. \u2013536. \u2013 P. 380-391.<br \/>\n21. \u0416\u0435\u043b\u0442\u043e\u043d\u043e\u0436\u0441\u043a\u0430\u044f \u0422.\u0411., \u041f\u043e\u043f \u0413.\u0421., \u0415\u0440\u0435\u043c\u0435\u043d\u043a\u043e \u0411.\u0412.,\u0423\u0441-\u043a\u043e\u0432 \u0418.\u0410. \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0441\u0432\u043e\u0439\u0441\u0442\u0432 \u0438 \u043a\u043e\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u0439 \u0432 \u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0435 \u0441\u043e\u043f\u043e\u043b\u0438\u043c\u0435\u0440\u0430 \u0441\u0442\u0438\u0440\u043e\u043b\u0430 \u0441 N,N-\u0434\u0438\u044d\u0442\u0438\u043b-\u0430\u043c\u0438\u043d\u043e\u043f\u0440\u043e\u043f\u0438\u043b-\u043c\u043e\u043d\u043e\u0430\u043c\u0438\u0434\u043e\u043c \u043c\u0430\u043b\u0435\u0438\u043d\u043e\u0432\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b \/\/ \u0412\u044b\u0441\u043e\u043a\u043e\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440. \u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f.- 1981.- 23, \u2116 11. \u2013 \u0421. 2425-2435.<br \/>\n22. \u041a\u0443\u043d\u0438\u0446\u044c\u043a\u0430 \u041b., \u0416\u0435\u043b\u0442\u043e\u043d\u043e\u0436\u0441\u044c\u043a\u0430 \u0422., \u0411\u0435\u0440\u043a\u043e\u0432\u0430 \u0421. \u041a\u0438\u043d\u0435\u0442\u0438\u043a\u0430 \u0431\u043b\u043e\u043a-\u043a\u043e\u043f\u043e\u043b\u0456\u043c\u0435\u0440\u0438\u0437\u0430\u0446\u0456\u0457 \u0430\u043a\u0440\u0438\u043b\u0430\u043c\u0456\u0434\u0443 \u0437 \u043c\u043e\u043d\u043e\u043c\u0435\u0442\u0438\u043b\u043e\u0432\u0438\u043c\u0438 \u0435\u0442\u0435\u0440\u0430\u043c\u0438 \u043f\u043e\u043b\u0456\u0435\u0442\u0438\u043b\u0435\u043d\u0433\u043b\u0456\u043a\u043e\u043b\u044e \u0440\u0456\u0437\u043d\u043e\u0457 \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0457 \u043c\u0430\u0441\u0438 \/\/ \u0412\u043e\u043f\u0440. \u0445\u0438\u043c\u0438\u0438 \u0438 \u0445\u0438\u043c. \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438.- 2007.- \u2116 3. \u2013 \u0421. 74-77.<br \/>\n23. \u0416\u0435\u043b\u0442\u043e\u043d\u043e\u0436\u0441\u043a\u0430\u044f \u0422.\u0411., \u0424\u0435\u0434\u043e\u0440\u0447\u0443\u043a \u0421.\u0412., \u0413\u043e\u043c\u0437\u0430 \u042e.\u041f., \u041f\u0435\u0440\u043c\u044f\u043a\u043e\u0432\u0430 \u041d.\u041c., \u0421\u044b\u0440\u043e\u043c\u044f\u0442\u043d\u0438\u043a\u043e\u0432 \u0412.\u0413. \u0412\u043b\u0438\u044f\u043d\u0438\u0435 \u0432\u043d\u0443\u0442\u0440\u0438\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u0433\u043e \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u043d\u0430 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u0443 \u0431\u043b\u043e\u043a-\u0441\u043e\u043f\u043e\u043b\u0438\u043c\u0435\u0440\u043e\u0432, \u0432\u043a\u043b\u044e\u0447\u0430\u044e\u0449\u0438\u0445 \u043f\u043e\u043b\u0438\u0430\u043a\u0440\u0438\u043b\u0430\u043c\u0438\u0434 \u0438 \u043f\u043e\u043b\u0438\u044d\u0442\u0438\u043b\u0435\u043d\u043e\u043a\u0441\u0438\u0434 \/\/ \u0412\u043e\u043f\u0440. \u0445\u0438\u043c\u0438\u0438 \u0438 \u0445\u0438\u043c. \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438. \u2013 2007. \u2013 8, \u2116 2. \u2013 \u0421. 78-87.<br \/>\n24. \u0424\u0435\u0434\u043e\u0440\u0447\u0443\u043a \u0421.\u0412., \u0416\u0435\u043b\u0442\u043e\u043d\u043e\u0436\u0441\u044c\u043a\u0430 \u0422.\u0411., \u041f\u0435\u0440\u043c\u044f\u043a\u043e- \u0432\u0430 \u041d.\u041c., \u0413\u043e\u043c\u0437\u0430 \u042e.\u041f., \u0411\u0430\u0440\u0430\u0431\u0430\u0448 \u041c.\u042e., \u041a\u0443\u043d\u0438\u0446\u044c\u043a\u0438\u0439 \u042e.\u0410. \u041d\u0430\u043d\u043e\u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440\u043e\u0432\u0430\u043d\u0456 A-b-B-b-A \u0442\u0440\u0438\u0431\u043b\u043e\u043a-\u043a\u043e\u043f\u043e\u043b\u0456\u043c\u0435\u0440\u0438 \u0437 \u0433\u0456\u0434\u0440\u043e\u0444\u0456\u043b\u044c\u043d\u0438\u043c\u0438 \u0445\u0456\u043c\u0456\u0447\u043d\u043e \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430\u0440\u043d\u0438\u043c\u0438 \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442\u0430\u043c\u0438 \/\/ \u041d\u0430\u043d\u043e\u0441\u0438\u0441\u0442\u0435\u043c\u0438, \u043d\u0430\u043d\u043e\u043c\u0430\u0442\u0435\u0440\u0456\u0430\u043b\u0438, \u043d\u0430\u043d\u043e\u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0456\u0457. &#8211; 2011. \u2013 8, \u2116 4. \u2013 \u0421. 869-889.<br \/>\n25. Kunitskaya L.R., Aleinichenko V.A., Zheltonozhskaya T.B., Berkova S.A. Nanostructured Triblock Copolymers, Forming Intramolecular Polycomplexes, for Solar Cells and Lithium Batteries \/\/ Mat.-wiss. u. Werkstofftech. \u2013 2010. \u2013 42, No. 2. \u2013 P. 109-113.<br \/>\n26. Zheltonozhskaya T. , Partsevskaya S., Fedorchuk S., Klymchuk D., Gomza Yu., Permyakova N., Kunitskaya L Micellar nanocontainers based on PAAm-b-PEO-b-PAAm<br \/>\ntriblock copolymers for poorly soluble drugs.\/\/ Europ. Polym. J. \u2013 2013. \u2013 49, No 2. \u2013 P. 405-418.<br \/>\n27. Kunitskaya L., Zheltonozhskaya T., Permyakova N., Kobylinska N. Double hydrophilic block copolymers for doxorubicin delivery\/\/ Mol. Cryst. Liq. Cryst. \u2013 2014. \u2013 590. \u2013 P. 164-171.<br \/>\n28. Riess G. Micellization of block copolymers \/\/ Prog. Polym. Sci. &#8211; 2003. &#8211; 28. \u2013 P. 1107\u20131170.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.15407\/polymerj.38.01.066 Micellar compositions with doxorubicin and their cytotoxicity \u00a0 L.R. Kunitskaya1, \u0422.B. Zheltonozhskaya1, R.S. Stoik\u04302, N.\u041c. Boiko2\u00a0 &nbsp; 1Kiev Taras Shevchenko National University 60 Vladimirskaya Str., 01033, Kiev, Ukraine 2Institute of Cell Biology NAS of Ukraine 14\/6 Dragomanova Str., 79005 Lviv, Ukraine &nbsp; Polym. J., 2016, 38, no. 1: 66-75. &nbsp; Section: Medical polymers. &nbsp; [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1809"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=1809"}],"version-history":[{"count":2,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1809\/revisions"}],"predecessor-version":[{"id":2182,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1809\/revisions\/2182"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=1809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}