{"id":1812,"date":"2018-01-10T14:59:35","date_gmt":"2018-01-10T11:59:35","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=1812"},"modified":"2018-02-14T15:53:01","modified_gmt":"2018-02-14T12:53:01","slug":"2016-1-10","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2016-1-10\/","title":{"rendered":"2016 (1) 10"},"content":{"rendered":"

https:\/\/doi.org\/10.15407\/polymerj.38.01.076<\/a><\/p>\n

\u03b2-Cyclodextrin-containing polymer systems with controlled release of drugs<\/strong><\/p>\n

\u00a0<\/em><\/strong><\/p>\n

L.A. Orel, L.V. Kobrina, S.I. Sinelnikov, S.V. Riabov<\/em><\/strong><\/p>\n

 <\/p>\n

Institute of Macromolecular Chemistry NAS of Ukraine<\/p>\n

48, Kharkivske shose, Kyiv, 02160, Ukraine<\/p>\n

 <\/p>\n

Polym. J., 2016, 38<\/strong>, no. 1: 76-80.<\/p>\n

 <\/p>\n

Section: Medical polymers.<\/p>\n

 <\/p>\n

Language: Ukrainian.<\/p>\n

 <\/p>\n

Abstract:<\/p>\n

In the work presented, the kinetics of desorption a most ubiquitous drugs (loratadine, diclofenac sodium, metoprolol succinate) from cyclodextrin-containing polymeric matrices is studied and the effect of functionalized \u03b2<\/em>-CD on the rate of desorption is established. It is found, that incorporation of \u03b2<\/em>-CD derivatives into polymer system changes a character of interaction between drug and polymer, allowing to influence the drug release mechanism. It is shown, that increase the degree of cross-linking of the polymer matrix to a certain level leads to enhancing of drugs desorption, but further increasing degree of cross-linking does not influence on drugs release. Incorporating of the \u03b2<\/em>-CD derivatives into polymer matrix results in slowing drugs desorption in 2\u20134 times. It is of interest for developing of a new drugs-polymer complexes with sustained release. Introduction of cyclodextrin derivatives in polymers can reduce the overall toxicity of drugs and stabilize them during storage.<\/em><\/p>\n

\u00a0<\/strong><\/p>\n

Key words: <\/strong>polymeric matrices, b<\/em>-CD derivatives, desorption, drugs.<\/p>\n

 <\/p>\n

\u041b\u0456\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u0430<\/strong><\/p>\n

1. \u041f\u043b\u0430\u0442\u044d \u041d.\u0410., \u0412\u0430\u0441\u0438\u043b\u044c\u0435\u0432 \u0412.\u0415. \u0424\u0438\u0437\u0438\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438 \u0430\u043a\u0442\u0438\u0432\u043d\u044b\u0435 \u043f\u043e\u043b\u0438\u043c\u0435\u0440\u044b. \u2013 \u041c.: \u0425\u0438\u043c\u0438\u044f, 1986. \u2013 294 \u0441.
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\n15. Liu Y.Y., Fan X.D. Synthesis, properties and controlled release behaviors of hydrogels networks using cyclodextrin as pendant groups \/\/ Biomaterials. \u2013 2005. \u2013 26. \u2013 P. 6367\u20136374.
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\n17. \u041b\u043e\u0432\u044f\u0433\u0438\u043d \u0410.\u041d. \u0423\u043d\u0438\u0432\u0435\u0440\u0441\u0430\u043b\u044c\u043d\u044b\u0439 \u0444\u0430\u0440\u043c\u0430\u0446\u0435\u0432\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u043f\u0440\u0430\u0432\u043e\u0447\u043d\u0438\u043a. \u2013 \u041c.: \u041e\u041e\u041e \u041f\u041a\u0424 \u201c\u0411\u0410\u041e\u201d, 2004. \u2013 608 \u0441.
\n18. \u041e\u043f\u0430\u043d\u0430\u0441\u0435\u043d\u043a\u043e \u041e.\u0410., \u0420\u044f\u0431\u043e\u0432 \u0421.\u0412., \u0421\u0456\u043d\u0435\u043b\u044c\u043d\u0456\u043a\u043e\u0432 \u0421.\u0406. \u0421\u0438\u043d\u0442\u0435\u0437 \u0456 \u0432\u043b\u0430\u0441\u0442\u0438\u0432\u043e\u0441\u0442\u0456 \u0437\u0448\u0438\u0442\u0438\u0445 \uf062-\u0446\u0438\u043a\u043b\u043e\u0434\u0435\u043a\u0441\u0442\u0440\u0438\u043d\u0432\u043c\u0456\u0441\u043d\u0438\u0445 \u043a\u043e\u043f\u043e\u043b\u0456\u043c\u0435\u0440\u0456\u0432 \u0442\u0430 \u0457\u0445\u043d\u044f \u0440\u043e\u043b\u044c \u0443 \u0444\u043e\u0442\u043e\u043a\u0430\u0442\u0430\u043b\u0456\u0442\u0438\u0447\u043d\u0438\u0445 \u043f\u0440\u043e\u0446\u0435\u0441\u0430\u0445 \/\/ \u0423\u043a\u0440. \u0445\u0456\u043c. \u0436\u0443\u0440\u043d. \u2013 2014. \u2013 80, \u2116 5-6. \u2013 \u0421. 58-63.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

https:\/\/doi.org\/10.15407\/polymerj.38.01.076 \u03b2-Cyclodextrin-containing polymer systems with controlled release of drugs \u00a0 L.A. Orel, L.V. Kobrina, S.I. Sinelnikov, S.V. Riabov   Institute of Macromolecular Chemistry NAS of Ukraine 48, Kharkivske shose, Kyiv, 02160, Ukraine   Polym. J., 2016, 38, no. 1: 76-80.   Section: Medical polymers.   Language: Ukrainian.   Abstract: In the work presented, the kinetics […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1812"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=1812"}],"version-history":[{"count":4,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1812\/revisions"}],"predecessor-version":[{"id":2184,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1812\/revisions\/2184"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=1812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}