{"id":1816,"date":"2018-01-10T15:04:27","date_gmt":"2018-01-10T12:04:27","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=1816"},"modified":"2018-02-14T15:54:50","modified_gmt":"2018-02-14T12:54:50","slug":"2016-1-11","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2016-1-11\/","title":{"rendered":"2016 (1) 11"},"content":{"rendered":"<p><a href=\"https:\/\/doi.org\/10.15407\/polymerj.38.01.081\">https:\/\/doi.org\/10.15407\/polymerj.38.01.081<\/a><\/p>\n<p><strong>Double-hydrophilic block copolymer micelles for drag delivery of poorly soluble vitamins in living organisms<\/strong><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<p><strong><em>N.M. Permyakova<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, T.B. Zheltonozhskaya<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, M.V. Ignatovskaya<\/em><\/strong><strong><em>2<\/em><\/strong><strong><em>, V.I. Maksin<\/em><\/strong><strong><em>2<\/em><\/strong><strong><em>, O.N. Iakubchak<\/em><\/strong><strong><em>2<\/em><\/strong><strong><em>, D.O. Klymchuk<\/em><\/strong><strong><em>3<\/em><\/strong><strong><em>, M.Ya. Poliyan<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, L.N. Grishchenko<\/em><\/strong><strong><em>1<\/em><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>1National Taras Shevchenko University of Kiev, Faculty of Chemistry<\/p>\n<p>60, Vladimirskaya str., Kyiv, 01033, Ukraine<\/p>\n<p>2\u00a0National University of Life and Environmental Sciences of Ukraine<\/p>\n<p>17, Heroyiv Oborony str., Kyiv, 03041, Ukraine<\/p>\n<p>3Institute of Botany NAS of Ukraine<\/p>\n<p>2, Tereschenkovskaya str., Kyiv, 01601, Ukraine<\/p>\n<p>&nbsp;<\/p>\n<p>Section: Medical polymers.<\/p>\n<p>&nbsp;<\/p>\n<p>Language: Ukrainian.<\/p>\n<p>&nbsp;<\/p>\n<p>Abstract:<\/p>\n<p><em>New effective biocompatible and partly biodegradable micellar nanocontainers for encapsulation and delivery of the vitamin E and it\u2019s analogues in the living organisms were created. Such micellar nanocaries are products of self-assembly of asymmetric block copolymers with chemically complementary (methoxy)poly(ethylene oxide) and poly(acrylic acid) blocks. The conditions of micellar structures formation, their parameters and morphology were studied by UV-Vis spectroscopy, static light scattering and transmission electron microscopy (TEM). It was shown, that the micellization process develops in aqueous media at pH&lt;5 due to hydrophobic interactions between non-polar bound segments of both blocks. The encapsulation of synthetic analogue of the vitamin E \u2013 <\/em><em>a<\/em><em>-Tocopherol acetate in created micellar nanocontainers could dramatically reduce the therapeutic doses of medication.<\/em><\/p>\n<p><strong>Keywords<\/strong>: block copolymer, intramolecular polycomplex, micelle, <em>a<\/em>-Tocopherol acetate, encapsulation.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u041b\u0456\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u0430<\/strong><\/p>\n<p>1. Torchilin V.P.(Ed.) Nanoparticulates as drug carriers. \u2013 London, Imperial College Press, 2006. \u2013 754 p.<br \/>\n2. Kwon G.S., Forrest M.L. Amphiphilic block copolymer micelles for nanoscale drug delivery \/\/ Drug. Develop. Res. \u2013 2006. \u2013 67. \u2013 P. 15-22.<br \/>\n3. \u0416\u0435\u043b\u0442\u043e\u043d\u043e\u0436\u0441\u044c\u043a\u0430 \u0422.\u0411., \u041d\u0435\u0434\u0430\u0448\u043a\u0456\u0432\u0441\u044c\u043a\u0430 \u0412.\u0412., \u0424\u0435\u0434\u043e\u0440\u0447\u0443\u043a \u0421.\u0412., \u041f\u0430\u0440\u0446\u0435\u0432\u0441\u044c\u043a\u0430 \u0421.\u0412., \u041f\u0435\u0440\u043c\u044f\u043a\u043e\u0432\u0430 \u041d.\u041c., \u041a\u043e\u0441\u0442\u0435\u043d\u043a\u043e \u041b.\u0421. \u041c\u0456\u0446\u0435\u043b\u044f\u0440\u043d\u0456 \u043d\u0430\u043d\u043e\u043a\u043e\u043d\u0442\u0435\u0439\u043d\u0435\u0440\u0438 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0456 \u0431\u043b\u043e\u043a-\u043a\u043e\u043f\u043e\u043b\u0456\u043c\u0435\u0440\u0456\u0432 \u0437 \u0445\u0456\u043c\u0456\u0447\u043d\u043e \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430\u0440\u043d\u0438\u043c\u0438 \u043a\u043e\u043c\u043f\u043e\u043d\u0435\u043d\u0442\u0430\u043c\u0438 \u0434\u043b\u044f \u0442\u043e\u043a\u0441\u0438\u0447\u043d\u0438\u0445 \u043d\u0435\u0440\u043e\u0437\u0447\u0438\u043d\u043d\u0438\u0445 \u0443 \u0432\u043e\u0434\u0456 \u043b\u0456\u043a\u0430\u0440\u0441\u044c\u043a\u0438\u0445 \u0441\u0443\u0431\u0441\u0442\u0430\u043d\u0446\u0456\u0439 \/\/ \u0414\u043e\u043f. \u041d\u0410\u041d \u0423\u043a\u0440\u0430\u0457\u043d\u0438. \u2013 2011. &#8211; \u2116 6. &#8211; \u0421. 143-150.<br \/>\n4. Ohya Y., Takahashi A., Nagahama K. Biodegradable polymeric assemblies for biomedical materials \/\/ Adv. Polym. Sci. \u2013 2012. \u2013 247. \u2013 P. 65-114.<br \/>\n5. Zhang Q., Ko N.R., Oh J.K. Recent advances in stimuli-responsive degradable block copolymer micelles: synthesis and controlled drug delivery applications \/\/ Chem. Commun. \u2013 2012. \u2013 48. \u2013 P. 7542-7552.<br \/>\n6. Letchford K., Burt H. A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes \/\/ Eur. J. Pharm. Biopharm. \u2013 2007. \u2013 65. \u2013 P. 259-269.<br \/>\n7. Pat. USA 5567433 \u0410. Liposome preparation and material encapsulation method \/ Collins D. \u2013 Publ. 1996.<br \/>\n8. Torchilin V.P. Multifunctional nanocarriers \/\/ Adv. Drug. Deliv. Rev. \u2013 2006. \u2013 58. P. 1532\u20131555.<br \/>\n9. Patent USA 8173167 B2. Micelle composition of polymer and passenger drug\/ Kwon G.S., Forrest M.L. \u2013 Publ. 2012.<br \/>\n10. \u0414\u043e\u043b\u0433\u043e\u043f\u043b\u043e\u0441\u043a \u0411.\u0410., \u0422\u0438\u043d\u044f\u043a\u043e\u0432\u0430 \u0415.\u0418. \u041e\u043a\u0438\u0441\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e-\u0432\u043e\u0441\u0441\u0442\u0430\u043d\u043e\u0432\u0438\u0442\u0435\u043b\u044c\u043d\u044b\u0435 \u0441\u0438\u0441\u0442\u0435\u043c\u044b \u043a\u0430\u043a \u0438\u0441\u0442\u043e\u0447\u043d\u0438\u043a\u0438 \u0441\u0432\u043e\u0431\u043e\u0434\u043d\u044b\u0445 \u0440\u0430\u0434\u0438\u043a\u0430\u043b\u043e\u0432. \u2013 \u041c.: \u041d\u0430\u0443\u043a\u0430, 1972. \u2013 240 \u0441.<br \/>\n11. \u041f\u0435\u0440\u043c\u044f\u043a\u043e\u0432\u0430 \u041d.\u041c. \u041a\u0456\u043d\u0435\u0442\u0438\u0447\u043d\u0456 \u0437\u0430\u043a\u043e\u043d\u043e\u043c\u0456\u0440\u043d\u043e\u0441\u0442\u0456 \u0431\u043b\u043e\u043a-\u043a\u043e\u043f\u043e\u043b\u0456\u043c\u0435\u0440\u0438\u0437\u0430\u0446\u0456\u0457 \u043f\u043e\u043b\u0456-\u0430\u043a\u0440\u0438\u043b\u043e\u0432\u043e\u0457 \u043a\u0438\u0441\u043b\u043e\u0442\u0438 \u0437 \u043c\u043e\u043d\u043e\u043c\u0435\u0442\u0438\u043b\u043e\u0432\u0438\u043c \u0435\u0442\u0435\u0440\u043e\u043c \u043f\u043e\u043b\u0456\u0435\u0442\u0438\u043b\u0435\u043d\u0433\u043b\u0456\u043a\u043e\u043b\u044e \/\/ \u041f\u043e\u043b\u0456\u043c\u0435\u0440. \u0436\u0443\u0440\u043d. \u2013 2008. \u2013 30, \u2116 3. \u2013 \u0421. 222-226.<br \/>\n12. Li P., Li Z., Huang J. Water-soluble star brush copolymer with four arms composed of poly(ethylene oxide) as backbone and poly(acrylic acid) as side chain \/\/ Macromolecules.-2007. \u2013 40. \u2013 P. 491-498.<br \/>\n13. Poe G. D., Jarrett W.L., Scales C.W., McCormick C.L. Enhanced coil expansion and intrapolymer complex formation of linear poly(methacrylic acid) containing poly(ethylene glycol) graft \/\/ Macromolecules. \u2013 2004. \u2013 37. \u2013 P. 2603-2612.<br \/>\n14. Shen H., Zang L., Eisenberg A. Thermodynamics of crew-cut micelle formation of polystyrene-b-poly(acrylic acid) diblock copolymers in DMF\/H2O mixtures \/\/ J. Phys. Chem. Part B. \u2013 1997. \u2013 101. \u2013 P. 4697-4708.<br \/>\n15. Permyakova N., Zheltonozhskaya T., Revko O., Grischenko L. Self-assembly and metalation of pH-sensitive double hydrophilic block copolymers with interacting polymer components \/\/ Macromol. Symp. -2012.- 317-318, \u2116 1. \u2013 P. 63-74.<br \/>\n16. \u041a\u0430\u0431\u0430\u043d\u043e\u0432 \u0412.\u0410., \u041f\u0430\u043f\u0438\u0441\u043e\u0432 \u0418.\u041c. \u041a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043e\u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u0435 \u043c\u0435\u0436\u0434\u0443 \u043a\u043e\u043c\u043f\u043b\u0435\u043c\u0435\u043d\u0442\u0430\u0440\u043d\u044b\u043c\u0438 \u0441\u0438\u043d\u0442\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u043c\u0438 \u043f\u043e\u043b\u0438\u043c\u0435\u0440\u0430\u043c\u0438 \u0438 \u043e\u043b\u0438\u0433\u043e\u043c\u0435\u0440\u0430\u043c\u0438 \u0432 \u0440\u0430\u0437\u0431\u0430\u0432\u043b\u0435\u043d\u043d\u044b\u0445 \u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0430\u0445 \/\/ \u0412\u044b\u0441\u043e\u043a\u043e\u043c\u043e\u043b. \u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f. \u0421\u0435\u0440. \u0410. \u2013 1979. \u2013 21, \u2116 2. \u2013 \u0421. 243-281.<br \/>\n17. Riess G. Micellization of block copolymers \/\/ Prog. Polym. Sci. \u2013 2003. &#8211; 28. &#8211; P. 1107\u20131170.<br \/>\n18. Alexandridis P., Hatton T.A. Block Copolymers. Polymer materials encyclopedia 1. \u2013 Boca Raton: CRC Press, 1996. \u2013 P. 743-754.<br \/>\n19. Zheltonozhskaya T., Partsevskaya S., Fedorchuk S., Klymchuk D., Gomza Yu., Permyakova N., Kunitskaya L. Micellar nanocontainers based on PAAm-b-PEO-b-PAAm triblock copolymers for poorly soluble drugs \/\/ Europ. Polym. J. \u2013 2013. \u201349, \u2116 2. \u2013 P. 405-418.<br \/>\n20. \u041a\u0435\u043d\u0447\u0438\u043d\u0433\u0442\u043e\u043d \u0410. \u0410\u043d\u0430\u043b\u0438\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043c\u0435\u0442\u043e\u0434\u044b \u0431\u0435\u043b\u043a\u043e\u0432\u043e\u0439 \u0445\u0438\u043c\u0438\u0438. \u041a\u0440\u0438\u0432\u044b\u0435 \u0442\u0438\u0442\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u2013 \u041c.: \u0418\u043d\u043e\u0441\u0442\u0440. \u043b-\u0440\u0430, 1963. \u2013 \u0421. 394-423.<br \/>\n21. \u0416\u0435\u043b\u0442\u043e\u043d\u043e\u0436\u0441\u043a\u0430\u044f \u0422.\u0411., \u041f\u043e\u043f \u0413.\u0421., \u0415\u0440\u0435\u043c\u0435\u043d\u043a\u043e \u0411.\u0412., \u0423\u0441-\u043a\u043e\u0432 \u0418.\u0410. \u0418\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0441\u0432\u043e\u0439\u0441\u0442\u0432 \u0438 \u043a\u043e\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0438\u0439 \u0432 \u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0435 \u0441\u043e\u043f\u043e\u043b\u0438\u043c\u0435\u0440\u0430 \u0441\u0442\u0438\u0440\u043e\u043b\u0430 \u0441 N,N-\u0434\u0438\u044d\u0442\u0438\u043b\u0430\u043c\u0438\u043d\u043e-\u043f\u0440\u043e\u043f\u0438\u043b\u043c\u043e\u043d\u043e\u0430\u043c\u0438\u0434\u043e\u043c \u043c\u0430\u043b\u0435\u0438\u043d\u043e\u0432\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b \/\/ \u0412\u044b\u0441\u043e\u043a\u043e-\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440. \u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u044f. \u0421\u0435\u0440. \u0410. \u2013 1981. \u2013 23, \u2116 11. \u2013 \u0421. 2425-2435.<br \/>\n22. \u041c\u0430\u043a\u043e\u0432\u0435\u0446\u044c\u043a\u0438\u0439 \u0412.\u041f., \u041c\u0430\u043a\u0441\u0456\u043d \u0412.\u0406., \u041a\u0443\u0440\u0430\u043f\u043e\u0432\u0430 \u0422.\u041c., \u0412\u043b\u0430\u0441\u0435\u043d\u043a\u043e \u0421.\u041e. \u0414\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043d\u044f \u0430\u043d\u0442\u0438\u0440\u0430\u0434\u0438\u043a\u0430\u043b\u044c\u043d\u043e\u0457 \u0442\u0430 \u0430\u043d\u0442\u0438\u043e\u043a\u0438\u0441\u043d\u044e\u0432\u0430\u043b\u044c\u043d\u043e\u0457 \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0456 \u0441\u043f\u043e\u043b\u0443\u043a \u041c\u0412-\u043f\u043e\u0445\u0456\u0434\u043d\u0438\u0445 \u043e\u043a\u0441\u0438\u0445\u0440\u043e\u043c\u0430\u043d\u0456\u0432 \u0442\u0430 \u0442\u0440\u0438\u043c\u0435\u0442\u0438\u043b\u0444\u0435\u043d\u043e\u043b\u0456\u0432. \/\/ \u0411\u0456\u043e\u0440\u0435\u0441\u0443\u0440\u0441\u0438 \u0456 \u043f\u0440\u0438\u0440\u043e\u0434\u043e\u043a\u043e\u0440\u0438\u0441\u0442\u0443\u0432\u0430\u043d\u043d\u044f. \u2013 2010. \u2013 \u2116 1-2. \u2013 \u0421. 28-33.<br \/>\n23. \u041f\u0440\u0435\u0447 \u042d., \u0411\u044e\u043b\u044c\u043c\u0430\u043d\u043d \u0424., \u0410\u0444\u0444\u043e\u043b\u044c\u0442\u0435\u0440 \u041a. \u041e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0441\u0442\u0440\u043e\u0435\u043d\u0438\u044f \u043e\u0440\u0433\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u0439. \u2013 \u041c\u043e\u0441\u043a\u0432\u0430: \u041c\u0438\u0440; \u0411\u0438\u043d\u043e\u043c. \u041b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u0438\u044f \u0437\u043d\u0430\u043d\u0438\u0439. \u2013 2006. \u2013 438 \u0441.<br \/>\n24. \u041b\u0435\u0432\u0447\u0435\u043d\u043a\u043e \u0412.\u0406. \u0412\u0435\u0442\u0435\u0440\u0438\u043d\u0430\u0440\u043d\u0430 \u043a\u043b\u0456\u043d\u0456\u0447\u043d\u0430 \u0431\u0456\u043e\u0445\u0456\u043c\u0456\u044f. \u2013 \u0411\u0456\u043b\u0430 \u0426\u0435\u0440\u043a\u0432\u0430, 2002. \u2013 400 c.<br \/>\n25. \u041f\u0440\u0438\u0445\u043e\u0434\u044c\u043a\u043e \u041e.\u041e. \u041c\u043e\u0440\u0444\u043e\u0444\u0443\u043d\u043a\u0446\u0456\u043e\u043d\u0430\u043b\u044c\u043d\u0456 \u0437\u043c\u0456\u043d\u0438 \u043f\u0435\u0440\u0438\u0444\u0435\u0440\u0438\u0447\u043d\u043e\u0457 \u043a\u0440\u043e\u0432\u0456 \u0432 \u0443\u043c\u043e\u0432\u0430\u0445 \u0434\u0456\u0457 \u0435\u043a\u0437\u043e\u0433\u0435\u043d\u043d\u0438\u0445 \u0447\u0438\u043d\u043d\u0438\u043a\u0456\u0432 \u0445\u0456\u043c\u0456\u0447\u043d\u043e\u0457 \u043f\u0440\u0438\u0440\u043e\u0434\u0438 \/\/ \u0412\u0456\u0441\u043d\u0438\u043a \u0421\u0443\u043c\u0441\u044c\u043a. \u0434\u0435\u0440\u0436. \u0443\u043d-\u0442\u0443. \u0421\u0435\u0440. \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0430. \u2013 2010. \u2013 \u2116 2. \u2013 \u0421. 42-47.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.15407\/polymerj.38.01.081 Double-hydrophilic block copolymer micelles for drag delivery of poorly soluble vitamins in living organisms \u00a0 N.M. Permyakova1, T.B. Zheltonozhskaya1, M.V. Ignatovskaya2, V.I. Maksin2, O.N. Iakubchak2, D.O. Klymchuk3, M.Ya. Poliyan1, L.N. Grishchenko1 &nbsp; 1National Taras Shevchenko University of Kiev, Faculty of Chemistry 60, Vladimirskaya str., Kyiv, 01033, Ukraine 2\u00a0National University of Life and Environmental Sciences [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1816"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=1816"}],"version-history":[{"count":2,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1816\/revisions"}],"predecessor-version":[{"id":2185,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1816\/revisions\/2185"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=1816"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}