{"id":1903,"date":"2018-01-10T16:36:11","date_gmt":"2018-01-10T13:36:11","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=1903"},"modified":"2018-02-14T18:01:31","modified_gmt":"2018-02-14T15:01:31","slug":"2015-2-13","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2015-2-13\/","title":{"rendered":"2015 (2) 13"},"content":{"rendered":"<p><a href=\"https:\/\/doi.org\/10.15407\/polymerj.37.02.193\">https:\/\/doi.org\/10.15407\/polymerj.37.02.193<\/a><\/p>\n<p><strong>Fluorescein-containing theranostics based on the pseudo-poly(amino acid)s for monitoring of drug delivery and release<\/strong><\/p>\n<p><strong><em>S. Varvarenko<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, V. Samaryk<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, V. Vlizlo<\/em><\/strong><strong><em>2<\/em><\/strong><strong><em>, D. Ostapiv<\/em><\/strong><strong><em>2<\/em><\/strong><strong><em>, N. Nosova<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, I. Tarnachyk<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, N. Fihurka<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, M. Ferens<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, M. Nagornyak<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, R. Taras<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, M. Yaremchuk<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>,<\/em><\/strong> <strong><em>A. Voronov<\/em><\/strong><strong><em>3<\/em><\/strong><strong><em>,<\/em><\/strong> <strong><em>S. Voronov<\/em><\/strong><strong><em>1<\/em><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>1Lviv Polytechnic National University<\/p>\n<p>12, S. Bandera str., Lviv, 79013, Ukraine<\/p>\n<p>2 Institute of animal biology NAAS of Ukraine<\/p>\n<p>38, V. Stus str., Lviv, 79034, Ukraine<\/p>\n<p>3North Dakota State University NDSU<\/p>\n<p>Dept. 2760, P.O. Box 6050 Fargo, North Dakota 58108-6050<\/p>\n<p>&nbsp;<\/p>\n<p>Polym. J., 2015, <strong>37<\/strong>, no. 2: 193-199.<\/p>\n<p>&nbsp;<\/p>\n<p>Section: Medical polymers.<\/p>\n<p>&nbsp;<\/p>\n<p>Language: Ukrainian.<\/p>\n<p>&nbsp;<\/p>\n<p>Abstract:<\/p>\n<p><em>The synthesis of amphiphilic pseudo-poly(amino acid)s (aminofunctional copolyesters) containing covalently grafted fluorescein was developed and structure thereof was confirmed. Such copolyesters colloidal properties allow using them as drug delivery carries providing visualization, drug transport and release. This allows considering them as so-called theranostics. Approbation of micellar solution of novel fluorescein-containing pseudo-poly(amino acid)s as carries in live cells showed their ability to penetrate into cells according to the fluorescent microscopy. <\/em><\/p>\n<p><em>The study of metabolism and live cells survival estimated the effect of amphiphilic fluorescein-containing pseudo-poly(amino acid)s on metabolic cell activity and cytotoxicity thereof. Thus, optimal limits of copolyester dosage \u2013 theranostic base \u2013 for usage in living biological objects were determined. <\/em><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Keywords: <\/strong>theranostic, pseudo-poly(amino acid), cell, metabolic.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u041b\u0456\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u0430<\/strong><\/p>\n<p>1. Torchilin. V.P. Multifunctional nanocarriers \/\/ Adv. Drug. Ddiv. Rev. &#8211; 2006. \u2013 59, \u2116 14. &#8211; P. 1532-1555.<br \/>\n2. Gross L., Ringsdorf H., Schupp H. Polymeric Anti-Tumor Agents on a Molecular and on a Cellular Level \/\/ Angrew. Chem. Int. Edit. &#8211; 1981. \u2013 20, \u2116 4. &#8211; P. 305-325.<br \/>\n3. S. Varvarenko, I. Tarnavchyk, A. Voronov et. Synthesis and colloidal properties of polyesters based on glutamic acids and glycols of different nature \/\/ Chemistry and Chemical Technology. &#8211; 2013. \u2013 7, \u2116 2. &#8211; P.164-168.<br \/>\n4. \u0412\u0430\u0440\u0432\u0430\u0440\u0435\u043d\u043a\u043e \u0421.\u041c., \u0424\u0456\u0433\u0443\u0440\u043a\u0430 \u041d.\u0412., \u0421\u0430\u043c\u0430\u0440\u0438\u043a \u0412.\u042f. \u0442\u0430 \u0456\u043d. \u0421\u0438\u043d\u0442\u0435\u0437 \u0442\u0430 \u043f\u043e\u0432\u0435\u0440\u0445\u043d\u0435\u0432\u043e-\u0430\u043a\u0442\u0438\u0432\u043d\u0456 \u0432\u043b\u0430\u0441\u0442\u0438\u0432\u043e\u0441\u0442\u0456 \u043d\u043e\u0432\u0438\u0445 \u043f\u043e\u043b\u0456\u0435\u0441\u0442\u0435\u0440\u0456\u0432 \u2013 \u043f\u0441\u0435\u0432\u0434\u043e\u043f\u043e\u043b\u0456\u0430\u043c\u0456\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0456 \u043f\u0440\u0438\u0440\u043e\u0434\u043d\u0438\u0445 \u0434\u0432\u043e\u043e\u0441\u043d\u043e\u0432\u043d\u0438\u0445 a-\u0430\u043c\u0456\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442 \/\/ \u0414\u043e\u043f. \u041d\u0410\u041d \u0423\u043a\u0440\u0430\u0457\u043d\u0438. &#8211; 2013. &#8211; \u2116 5. &#8211; \u0421. 131-139.<br \/>\n5. \u0412\u0430\u0440\u0432\u0430\u0440\u0435\u043d\u043a\u043e \u0421.\u041c., \u0424\u0456\u0433\u0443\u0440\u043a\u0430 \u041d.\u0412., \u0421\u0430\u043c\u0430\u0440\u0438\u043a \u0412.\u042f. \u0442\u0430 \u0456\u043d. \u041d\u043e\u0432\u0456 \u0430\u043c\u0444\u0456\u0444\u0456\u043b\u044c\u043d\u0456 \u043f\u043e\u043b\u0456\u0435\u0441\u0442\u0435\u0440\u0438 \u043f\u0441\u0435\u0432\u0434\u043e\u043f\u043e\u043b\u0456\u0430\u043c\u0456\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442\u0438 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0456 \u043f\u0440\u0438\u0440\u043e\u0434\u043d\u0438\u0445 \u0434\u0432\u043e\u043e\u0441\u043d\u043e\u0432\u043d\u0438\u0445 \u0430\u043c\u0456\u043d\u043e\u043a\u0438\u0441\u043b\u043e\u0442 \u0442\u0430 \u0434\u0456\u043e\u043b\u0456\u0432, \u043e\u0434\u0435\u0440\u0436\u0430\u043d\u0456 \u0447\u0435\u0440\u0435\u0437 \u0440\u0435\u0430\u043a\u0446\u0456\u044e \u0435\u0441\u0442\u0435\u0440\u0438\u0444\u0456\u043a\u0430\u0446\u0456\u0457 \u0421\u0442\u0435\u0433\u043b\u0456\u0445\u0430 \/\/ \u041f\u043e\u043b\u0456\u043c\u0435\u0440. \u0436\u0443\u0440\u043d. &#8211; 2013. \u2013 35, \u2116 3. \u2013 \u0421. 282-290.<br \/>\n6. Shimizu N, Kawazoe Y. A new method for permeabilization of the plasma membrane of cultured mammalian cells. III. Intemalization of fluorescent dextrans into cultured mammalian cells by vortex-stirring in the presence of high molecular weight polyacrylic acid. \/\/ Biol. Pharm Bull. &#8211; 1996. \u2013 19, \u2116 8. &#8211; P. 1023-1028.<br \/>\n7. \u0411\u0430\u0440\u0441\u043a\u0438\u0439 \u0418.\u042f., \u041f\u043e\u043b\u044f\u043a\u043e\u0432 \u041d.\u0418., \u042f\u043a\u0443\u0431\u0441\u043d\u0430\u0441 \u0412.\u0410. \u041a\u043e\u043d\u0442\u0430\u043a\u0442\u043d\u0430\u044f \u043c\u0438\u043a\u0440\u043e\u0441\u043a\u043e\u043f\u0438\u044f. &#8211; \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430, 1976. &#8211; 159 \u0441.<br \/>\n8. \u0424\u0440\u0430\u0439\u0448\u0442\u0430\u0442 \u0414.\u041c. \u0420\u0435\u0430\u043a\u0442\u0438\u0432\u044b \u0438 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u044b \u0434\u043b\u044f \u043c\u0438\u043a\u0440\u043e\u0441\u043a\u043e\u043f\u0438\u0438. &#8211; \u041c.: \u0425\u0438\u043c\u0438\u044f, 1980. &#8211; 480 \u0441.<br \/>\n9. \u0412\u0430\u0439\u0441\u0431\u0435\u0440\u0433 \u0410., \u041f\u0440\u043e\u0441\u043a\u0430\u0443\u044d\u0440 \u042d., \u0420\u0438\u0434\u0434\u0438\u0441 \u0414. \u0438 \u0434\u0440. \u041e\u0440\u0433\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0438\u0442\u0435\u043b\u0438. \u2013 \u041c.: \u0418\u043d\u043e\u0441\u0442\u0440. \u043b-\u0440\u0430, 1976. \u2013 541 \u0441.<br \/>\n10. \u041a\u0430\u0437\u0438\u0446\u0438\u043d\u0430 \u041b.\u0410., \u041a\u0443\u043f\u043b\u0435\u0442\u0441\u043a\u0430\u044f \u041d.\u0411. \u041f\u0440\u0438\u043c\u0435\u043d\u0435\u043d\u0438\u0435 \u0423\u0424-, \u0418\u041a-, \u042f\u041c\u0420- \u0441\u043f\u0435\u043a\u0442\u0440\u043e\u0441\u043a\u043e\u043f\u0438\u0438 \u0432 \u043e\u0440\u0433\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u0445\u0438\u043c\u0438\u0438. \u2013 \u041c.: \u0412\u044b\u0441\u0448\u0430\u044f \u0448\u043a\u043e\u043b\u0430, 1971. \u2013 264 \u0441.<br \/>\n11. \u0411\u0435\u043b\u0430\u043c\u0438 \u041b. \u0418\u043d\u0444\u0440\u0430\u043a\u0440\u0430\u0441\u043d\u044b\u0435 \u0441\u043f\u0435\u043a\u0442\u0440\u044b \u0441\u043b\u043e\u0436\u043d\u044b\u0445 \u043c\u043e\u043b\u0435\u043a\u0443\u043b.\/ \u0411\u0435\u043b\u0430\u043c\u0438 \u041b. [\u041f\u0435\u0440. \u0441 \u0430\u043d\u0433\u043b\u0438\u0439\u0441\u043a\u043e\u0433\u043e \u0410\u043a\u0438\u043c\u043e\u0432\u0430 \u0412.\u041c., \u041f\u0435\u043d\u0442\u0438\u043d\u0430 \u042e.\u0410., \u0422\u0435\u0442\u0435\u0440\u0438\u043d\u0430 \u042e.\u0413. \u043f\u043e\u0434 \u0440\u0435\u0434. \u041f\u0435\u043d\u0442\u0438\u043d\u0430 \u042e.\u0410.]. \u2013 \u041c.: \u0418\u0437\u0434-\u0432\u043e \u0438\u043d\u043e\u0441\u0442\u0440. \u043b-\u0440\u044b, 1963. \u2013 590 \u0441.<br \/>\n12. Workman J. Handbook of Organic Compounds. Ni, Ir, Raman, and Uv-Vis Spectra Featuring Polymers and Surficants \/\/ San Diego: Buckram Pablisher. AcademicPress. &#8211; 2001. \u2013 428 p.<br \/>\n13. \u0422\u043e\u0440\u043e\u043f\u0446\u0435\u0432\u0430 \u0410.\u041c., \u0411\u0435\u043b\u043e\u0433\u043e\u0440\u043e\u0434\u0441\u043a\u0430\u044f \u041a.\u0412., \u0411\u043e\u043d\u0434\u0430\u0440\u0435\u043d- \u043a\u043e \u0412.\u041c. \u041b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0443\u043c \u043f\u043e \u0445\u0438\u043c\u0438\u0438 \u0438 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0432\u044b\u0441\u043e\u043a\u043e\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0445 \u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u0439. \u2013 \u041b.: \u0425\u0438\u043c\u0438\u044f, 1976. \u2013 415 \u0441.<br \/>\n14. \u0410\u043c\u043f\u0435\u0440\u043e\u043c\u0435\u0442\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u043e\u043f\u0440\u0435\u0434\u0435\u043b\u0435\u043d\u0438\u0435 \u0444\u0435\u0440\u0440\u043e\u0446\u0438\u0430\u043d\u0438\u0434\u0430 \u0432 \u043f\u0440\u0438\u0441\u0443\u0442\u0441\u0442\u0432\u0438\u0438 \u0441\u0443\u0431\u043a\u043b\u0435\u0442\u043e\u0447\u043d\u044b\u0445 \u0441\u0442\u0440\u0443\u043a\u0442\u0443\u0440 \/ \u041a.\u0424. \u0428\u0442\u043e\u043b\u044c\u0446, \u0418.\u041c. \u041c\u043e\u0441\u043e\u043b\u043e\u0432\u0430, \u041b.\u0410. \u0414\u0440\u043e\u043d\u043e\u0432\u0430. \u0411\u0438\u043e\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043c\u0435\u0442\u043e\u0434\u044b. \u2013 \u041c.: \u041d\u0430\u0443\u043a\u0430, 1980. \u2013 \u0421. 147\u2013150.<br \/>\n15. \u0427\u0443\u0445\u0440\u0456\u0439 \u0411.\u041c., \u041a\u043b\u0435\u0432\u0435\u0446\u044c \u041b.\u041e., \u041e\u0441\u0442\u0430\u043f\u0456\u0432 \u0414.\u0414. \u041a\u043e\u043b\u043e\u0440\u0438\u043c\u0435\u0442\u0440\u0438\u0447\u043d\u0438\u0439 \u0441\u043f\u043e\u0441\u0456\u0431 \u0432\u0438\u0437\u043d\u0430\u0447\u0435\u043d\u043d\u044f \u0430\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u0456 \u0441\u0443\u043a\u0446\u0438\u043d\u0430\u0442\u0434\u0435\u0433\u0456\u0434\u0440\u043e\u0433\u0435\u043d\u0430\u0437\u0438 \u0432 \u0441\u043f\u0435\u0440\u043c\u0456 \u0431\u0443\u0433\u0430\u0457\u0432. \/\/ \u0412\u0456\u0441\u043d. \u0430\u0433\u0440\u0430\u0440\u043d\u043e\u0457 \u043d\u0430\u0443\u043a\u0438, 1995. \u2013 \u2116 11. \u2013 \u0421. 73\u201375.<br \/>\n16. \u041f\u043b\u043e\u0445\u0438\u043d\u0441\u043a\u0438\u0439 \u041d.\u0410. \u0411\u0438\u043e\u043c\u0435\u0442\u0440\u0438\u044f. \u2013 \u041c.: \u041c\u0413\u0423, 1970. \u2013 \u0421. 53\u201360.<br \/>\n17. Jang Y.H., Hwang S., Chung D.S. \/\/ Chem. Lett. \u2013 2001. \u2013 P. 1316-1317.<br \/>\n18. \u041c\u0447\u0435\u0434\u043b\u043e\u0432-\u041f\u0435\u0442\u0440\u043e\u0441\u044f\u043d \u041d.\u041e. \u0424\u043b\u0443\u043e\u0440\u0435\u0441\u0446\u0435\u0438\u043d\u043e\u0432\u044b\u0435 \u043a\u0440\u0430\u0441\u0438\u0442\u0435\u043b\u0438 \u0432 \u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0430\u0445 \u2013 \u0445\u043e\u0440\u043e\u0448\u043e \u0438\u0437\u0443\u0447\u0435\u043d\u043d\u044b\u0435 \u0441\u0438\u0441\u0442\u0435\u043c\u044b? \/\/ \u0412\u0456\u0441\u043d. \u0425\u0430\u0440\u043a\u0456\u0432. \u043d\u0430\u0446. \u0443\u043d-\u0442\u0443. \u2013 2004. \u2013 \u2116 626. \u0425\u0456\u043c\u0456\u044f. \u2013 \u0412\u0438\u043f. 11(34). \u2013 \u0421. 221\u2013312.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.15407\/polymerj.37.02.193 Fluorescein-containing theranostics based on the pseudo-poly(amino acid)s for monitoring of drug delivery and release S. Varvarenko1, V. Samaryk1, V. Vlizlo2, D. Ostapiv2, N. Nosova1, I. Tarnachyk1, N. Fihurka1, M. Ferens1, M. Nagornyak1, R. Taras1, M. Yaremchuk1, A. Voronov3, S. Voronov1 &nbsp; 1Lviv Polytechnic National University 12, S. Bandera str., Lviv, 79013, Ukraine 2 Institute [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1903"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=1903"}],"version-history":[{"count":2,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1903\/revisions"}],"predecessor-version":[{"id":2227,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1903\/revisions\/2227"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=1903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}