{"id":1948,"date":"2018-01-10T17:50:52","date_gmt":"2018-01-10T14:50:52","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=1948"},"modified":"2018-02-14T17:30:47","modified_gmt":"2018-02-14T14:30:47","slug":"2015-3-12","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2015-3-12\/","title":{"rendered":"2015 (3) 12"},"content":{"rendered":"<p><a href=\"https:\/\/doi.org\/10.15407\/polymerj.37.03.299\">https:\/\/doi.org\/10.15407\/polymerj.37.03.299<\/a><\/p>\n<p><strong>Synthesis of surface-active cholesterylcontaining copolymers based on poly(maleic anhydride-co-ethyltrioxyethylene methacrylate)<\/strong><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<p><strong><em>Z.I. Demchuk<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, <\/em><\/strong><strong><em>\u041e<\/em><\/strong><strong><em>.G. Budishevska<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, <\/em><\/strong><strong><em>\u0410<\/em><\/strong><strong><em>.S. Voronov<\/em><\/strong><strong><em>2<\/em><\/strong><strong><em>, V.B. Vostres<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, I.T. Tarnavchyk<\/em><\/strong><strong><em>1,2<\/em><\/strong><strong><em>, <\/em><\/strong><strong><em>\u041c<\/em><\/strong><strong><em>.Z. Savka<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, <\/em><\/strong><strong><em>\u041e<\/em><\/strong><strong><em>.Yu. Zholobko<\/em><\/strong><strong><em>1<\/em><\/strong><strong><em>, S.A. Voronov<\/em><\/strong><strong><em>1<\/em><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>1Lviv Polytechnic National University<\/p>\n<p>12, S.Bandery STR, Lviv, 79013, Ukraine<\/p>\n<p>2North Dakota State University<\/p>\n<p>Dept. 2760, P.O. Box 6050, Fargo, ND 58108-6050, USA<\/p>\n<p>&nbsp;<\/p>\n<p>Polym. J., 2015, <strong>37<\/strong>, no. 3: 299-305.<\/p>\n<p>&nbsp;<\/p>\n<p>Section: Synthesis polymers.<\/p>\n<p>&nbsp;<\/p>\n<p>Language: Ukrainian.<\/p>\n<p>&nbsp;<\/p>\n<p>Abstract:<\/p>\n<p><em>Amphiphilic surfactants poly(cholesterylmaleinat-co-maleic acid-co-ethylltrioxyethylene methacrylate) (MA<\/em><em>c<\/em><em>-CholMA<\/em><em>c<\/em><em>-PEMA) with different contents of cholesteryl were synthesized by the reaction of cholesterol with a poly(maleic anhydride-co-ethyltrioxyethylene methacrylate) copolymer and followed by alkaline hydrolysis of poly(cholesterylmaleinat-co-maleic acid-co-ethylltrioxyethylene methacrylate)(CholMA<\/em><em>c<\/em><em>-MA-PEMA). The structures of obtained copolymers were studied with an IR and a <\/em><em>1<\/em><em>H-NMR spectroscopy, a pH-metric titration. Aqueous colloids of procured copolymers are able to solubilize lipophilic substances.<\/em><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Keywords:<\/strong> cholesterylcontaining copolymers, poly(maleic anhydride-co-ethyltrioxyethylene methacrylate), solubilization of lipophilic substances.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u041b\u0456\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u0430<\/strong><\/p>\n<p>1. Hua Song, Rong He, Kan Wang, Jing Ruan, Chenchen Bao, Na Li, Jiajia Ji, Daxiang Cui Anti-HIF-1a antibody-conjugated pluronic triblock copolymers encapsulated with Paclitaxel for tumor targeting therapy \/\/ Biomaterials.- 2010.-31(8).-\u0420. 2302-2312..<br \/>\n2. Nill Bergstrand Liposomes for Drug Delivery from Physico-chemical Studies to Applications \/\/ Dissertation in Physical Chemistry to be publicly examined in B41, BMC, Uppsala University.- May 25, 2003.<br \/>\n3. Song Y., Tian Q., Huang Z., Fan D., She Z., Liu X., Cheng X., Yu B., Deng Y. Self-assembled micelles of novel amphiphilic copolymer cholesterol-coupled F68 containing cabazitaxel as a drug delivery system \/\/ International J. of Nanomedicine. \u2013 2014.- 9, \u2116 1.- P. 2307-2317.<br \/>\n4. Jian-Ping Xu, Jian Ji*, Wei-Dong Chen, Jia-Cong Shen Novel biomimetic polymersomes as polymer therapeutics for drug delivery \/\/ J. of Controlled Release.- 2005.- 107.- \u0420. 502-512.<br \/>\n5. Lijuan Zhang, Xindong Guo, Yu Qian Quantitative structure-activity relationship in the sustained drug delivery systems \/\/ 20th European Symposium on Computer Aided Process Engineering \u2013 ESCAPE20 S. Pierucci and G. Buzzi Ferraris (Editors).<br \/>\n6. Yang Dan-boa, Zhu Jia-bi, Huang Zhang-jian, Ren Hai-xia, Zheng Zeng-juan Synthesis and application of poly(ethyleneglycol)\u2013cholesterol (Chol\u2013PEGm) conjugates in physicochemical characterization of nonionic surfactant vesicles \/\/ Colloids and Surfaces. Part B: Biointerfaces \u2013 2008.- 63.- P.192\u2013199.<br \/>\n7. Lin Jia, Di Cui, Jerome Bignon, Aurelie Di Cicco, Joanna Wdzieczak-Bakala, Jianmiao Liu, Min-Hui Li Reduction-Responsive Cholesterol-Based Block Copolymer Vesicles for Drug Delivery \/\/ Biomacromolecules.-2014.- 15, \u21166.-P.2206-2217.<br \/>\n8. Chi Thanh Nguyen, Thanh Huyen Tran, Xiuling Lub, Rajeswari M. Kasi Self-assembled nanoparticles from thiol functionalized liquid crystalline brush block copolymers for dual encapsulation of doxorubicin and gold nanoparticles \/\/ Polym. Chem.- 2014.- 5.-P.2774-2783.<br \/>\n9.Bedu-Addo R.K., Tang P., Xu Y., Huang L. Interaction of Polyethyleneglycol-Phospholipid Conjugates with Cholesterol-Phosphatidylcholine Mixtures: Sterically Stabilized Liposome Formulations \/\/ Pharmaceutical Research.-1996.- 13, \u2116 5.-P.718-725.<br \/>\n10. Liu Y., Wang Y., Zhuang D., Yang J., Yang J. Bionanoparticles of amphiphilic copolymers polyacrylate bearing cholesterol and ascorbate for drug delivery \/\/ J. Colloid Interface Sci. \u2013 2012.- 377, \u21161.-P.197-206.<br \/>\n11. Sevimli S., Inci F., Zareie H.M., Bulmus V. Well-defined cholesterol polymers with pH-controlled membrane switching activity \/\/ Biomacromolecules.- 2012. &#8211; 8, \u2116 13(10). &#8211; P. 3064-75.<br \/>\n12. \u0412\u0430\u0439\u0441\u0431\u0435\u0440\u0433 \u0410., \u041f\u0440\u043e\u0441\u043a\u0430\u0443\u044d\u0440 \u042d., \u0420\u0438\u0434\u0434\u0438\u0441 \u0414., \u0422\u0443\u043f\u0441 \u042d. \u041e\u0440\u0433\u0430\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0440\u0430\u0441\u0442\u0432\u043e\u0440\u0438\u0442\u0435\u043b\u0438. \u041c.: \u0418\u043d\u043e\u0441\u0442\u0440. \u043b-\u0440\u0430, 1976. &#8211; 541 \u0441.<br \/>\n13. \u0422\u043e\u0440\u043e\u043f\u0446\u0435\u0432\u0430 A.M., \u0411\u0435\u043b\u043e\u0433\u043e\u0440\u043e\u0434\u0441\u043a\u0430\u044f \u041a.\u0412., \u0411\u043e\u043d\u0434\u0430\u0440\u0435\u043d- \u043a\u043e \u0412.\u041c. \u041b\u0430\u0431\u043e\u0440\u0430\u0442\u043e\u0440\u043d\u044b\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0443\u043c \u043f\u043e \u0445\u0438\u043c\u0438\u0438 \u0438 \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u0438 \u0432\u044b\u0441\u043e\u043a\u043e\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u044b\u0445 \u0441\u043e\u0435\u0434\u0438\u043d\u0435\u043d\u0438\u0439. \u2013 \u041b.: \u0425\u0438\u043c\u0438\u044f, 1972. \u2013 416 \u0441.<br \/>\n14. \u041d\u0435\u0439\u043c\u0430\u043d \u0420.\u042d., \u0412\u0435\u0440\u0435\u0436\u043d\u0438\u043a\u043e\u0432, \u0412.\u041d., \u041a\u0438\u0440\u0434\u0435\u0435\u0432\u0430 \u0410.\u041f., \u041a\u0438\u0441\u0435\u043b\u0435\u0432\u0430 \u041e.\u0413., \u041b\u0435\u0431\u0435\u0434\u0435\u0432\u0430 \u0418.\u041d. \u041f\u0440\u0430\u043a\u0442\u0438\u043a\u0443\u043c \u043f\u043e \u043a\u043e\u043b\u043b\u043e\u0438\u0434\u043d\u043e\u0439 \u0445\u0438\u043c\u0438\u0438 \u043b\u0430\u0442\u0435\u043a\u0441\u043e\u0432 \u0438 \u043f\u043e\u0432\u0435\u0440\u0445\u043d\u043e\u0441\u0442\u043d\u043e-\u0430\u043a\u0442\u0438\u0432\u043d\u044b\u0445 \u0432\u0435\u0449\u0435\u0441\u0442\u0432.- \u041c.: \u0412\u044b\u0441\u0448\u0430\u044f \u0448\u043a\u043e\u043b\u0430, 1972. \u2013 176 \u0441.<br \/>\n15. \u0412.\u042e. \u041a\u043e\u043d\u044e\u0445\u043e\u0432 \u041f\u043e\u043b\u0438\u043c\u0435\u0440\u044b \u0438 \u043a\u043e\u043b\u043b\u043e\u0438\u0434\u043d\u044b\u0435 \u0441\u0438\u0441\u0442\u0435\u043c\u044b: \u0423\u0447\u0435\u0431\u043d\u043e\u0435 \u043f\u043e\u0441\u043e\u0431\u0438\u0435. &#8211; \u041c: \u041c\u0413\u0423\u041f, 1999. &#8211; 101 \u0441.<br \/>\n16. Raoul Zana Dinamics of surfactant self-assemblies Micelles, Microemulsions, Vesicles, and Lyotropic Phases \/\/ Surfactant science series.- CRC Press Taylor&amp;Francis Group. &#8211; 2005. &#8211; Vol.125. &#8211; P. 161-232.<br \/>\n17. \u041d\u0438\u0444\u0430\u043d\u0442\u044c\u0435\u0432 \u0418.\u042d., \u0418\u0432\u0447\u0435\u043d\u043a\u043e \u041f.\u0412. \u041f\u0440\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u043a\u0443\u0440\u0441 \u0441\u043f\u0435\u043a\u0442\u0440\u043e\u0441\u043a\u043e\u043f\u0438\u0438 \u044f\u0434\u0435\u0440\u043d\u043e\u0433\u043e \u043c\u0430\u0433\u043d\u0438\u0442\u043d\u043e\u0433\u043e \u0440\u0435\u0437\u043e\u043d\u0430\u043d\u0441\u0430. &#8211; \u041c\u043e\u0441\u043a\u0432\u0430, 2006. \u2013 200 \u0441.<br \/>\n18. \u0411\u0430\u0431\u0430\u043a \u0412.\u0413. \u0412\u044b\u0441\u043e\u043a\u043e\u043a\u043e\u043d\u0446\u0435\u043d\u0442\u0440\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u044d\u043c\u0443\u043b\u044c\u0441\u0438\u0438. \u0424\u0438\u0437\u0438\u043a\u043e-\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u0440\u0438\u043d\u0446\u0438\u043f\u044b \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u044f \u0438 \u0443\u0441\u0442\u043e\u0439\u0447\u0438\u0432\u043e\u0441\u0442\u044c \/\/ \u0423\u0441\u043f\u0435\u0445\u0438 \u0445\u0438\u043c\u0438\u0438.- 2008.- 77, \u2116 8. &#8211; \u0421. 729-756.<br \/>\n19. \u0412\u043e\u0440\u043e\u043d\u043e\u0432 \u0421.\u0410., \u0412\u0430\u0440\u0432\u0430\u0440\u0435\u043d\u043a\u043e \u0421.\u041c. \u041f\u0435\u0440\u043e\u043a\u0441\u0438\u0434\u043e\u0432\u043c\u0456\u0441\u043d\u0456 \u043c\u0430\u043a\u0440\u043e\u043c\u043e\u043b\u0435\u043a\u0443\u043b\u0438 \u043d\u0430 \u043c\u0435\u0436\u0456 \u0440\u043e\u0437\u0434\u0456\u043b\u0443 \u0444\u0430\u0437. \u2013 \u041b\u044c\u0432\u0456\u0432: \u041b\u044c\u0432\u0456\u0432\u0441\u044c\u043a\u0430 \u043f\u043e\u043b\u0456\u0442\u0435\u0445\u043d\u0456\u043a\u0430, 2011. \u2013 333 \u0441.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.15407\/polymerj.37.03.299 Synthesis of surface-active cholesterylcontaining copolymers based on poly(maleic anhydride-co-ethyltrioxyethylene methacrylate) \u00a0 Z.I. Demchuk1, \u041e.G. Budishevska1, \u0410.S. Voronov2, V.B. Vostres1, I.T. Tarnavchyk1,2, \u041c.Z. Savka1, \u041e.Yu. Zholobko1, S.A. Voronov1 &nbsp; 1Lviv Polytechnic National University 12, S.Bandery STR, Lviv, 79013, Ukraine 2North Dakota State University Dept. 2760, P.O. Box 6050, Fargo, ND 58108-6050, USA &nbsp; Polym. J., [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1948"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=1948"}],"version-history":[{"count":2,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1948\/revisions"}],"predecessor-version":[{"id":2210,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1948\/revisions\/2210"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=1948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}