{"id":1954,"date":"2018-01-10T17:57:33","date_gmt":"2018-01-10T14:57:33","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=1954"},"modified":"2018-02-14T16:54:50","modified_gmt":"2018-02-14T13:54:50","slug":"2015-4-1","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2015-4-1\/","title":{"rendered":"2015 (4) 1"},"content":{"rendered":"<p><a href=\"https:\/\/doi.org\/10.15407\/polymerj.37.04.330\">https:\/\/doi.org\/10.15407\/polymerj.37.04.330<\/a><\/p>\n<p><strong>Polymer hydrogels based on cyclodextrins as carriers for drugs: synthesis and physicochemical properties<\/strong><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<p><strong><em>L.A. Orel, S.V. Riabov, L.V. Kobrina, L.A. Goncharenko <\/em><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>Institute of Macromolecular Chemistry the NAS of Ukraine<\/p>\n<p>48, Kharkivske shose, Kyiv, 02160, Ukraine<\/p>\n<p>&nbsp;<\/p>\n<p>Polym. J., 2015, <strong>37<\/strong>, no. 4: 330-340.<\/p>\n<p>&nbsp;<\/p>\n<p>Section: Review.<\/p>\n<p>&nbsp;<\/p>\n<p>Language: Ukrainian.<\/p>\n<p>&nbsp;<\/p>\n<p>Abstract:<\/p>\n<p><em>In a review article the problems of creating hydrogels as carriers for systems with controlled release of drugs were analyzed. Polymers, especially those intended for biomedical purposes, in particular for transport of drugs, must have high compatibility with biological tissues and the ability to biodegradation. The best for such requirements the systems based on natural polymers, in particular cyclodextrins suites. The development of advanced materials, new methods of synthesis allows to create unique polymer products, such as soft contact lenses with high gas permeability, bearing water-insoluble drugs, sorbents capable of absorbing both hydrophilic and hydrophobic substances, new membrane materials and other objects.<\/em><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Key words: <\/strong>polymer hydrogels, cyclodextrins, inclusion complexes, drug, release kinetics.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u041b\u0456\u0442\u0435\u0440\u0430\u0442\u0443\u0440\u0430<\/strong><\/p>\n<p>1. Alvarez Lorenzo C., Rosa dos Santos J.F., Sosnik A., Torres Labandeira J.J., Concheiro A. Hydrogels with cyclodextrins as highly versatile drug delivery systems. \u2013 In: Hanbook of Hydrogels: Properties, Preparation and Applications, D.B. Stein Ed. \/\/ Nova Science Publishers. \u2013 2009. \u2013 P. 1-42.<br \/>\n2. Irie T., Uekama K. Pharmaceutical Applications of cyclodextrins-Toxicological issues and safety evaluation. \/\/ J. Pharm Sci. \u20131997. \u2013 86. \u2013 P. 147-162.<br \/>\n3. Uekama K., Horiuchi Y., Kikuchi M., Hirayama F. Enhanced dissolution and oral bioavailability of \uf061-tocopheryl esters by dimethyl-\uf062-cyclodextrin complexation. \/\/ J. Incl. Phenom. \u2013 1988. \u2013 6. \u2013 P. 167-174.<br \/>\n4. Loftsson T., Kristmundsdottir T. Microcapsules containing water- soluble cyclodextrin inclusion complexes of water-insoluble drugs. \/\/ ACS Sym. Ser. \u2013 1993. \u2013 520. \u2013 P. 168-189.<br \/>\n5. Wichterle O., Lim D. Hydrophilic gels for biological use. \/\/ Nature. \u2013 1960. \u2013 185. \u2013 P. 117-118.<br \/>\n6. Baker R.W., Tuttle M.E., Helwing R. Novel Erodible Polymers for the Delivery of Macromolecules. \/\/ Pharm.Technol. \u2013 1984. \u2013 8. \u2013 P. 26, 28, 30.<br \/>\n7. Kashyap N., Kumar N., Kumar M. Hydrogels for pharmaceutical and biomedical applications. \/\/ Crit. Rev. Ther. Drug Carr. Syst. \u2013 2005. \u2013 22. \u2013 P. 107-149.<br \/>\n8. Hoffman A.S. Hydrogels for biomedical applications. \/\/ Adv. Drug Deliv. Rev. \u2013 2002. \u2013 43. \u2013 P. 3-12.<br \/>\n9. Peppas N.A., Mikos A.G. Preparation methods and structure of hydrogels, in: N.A. Peppas (Ed.), Hydrogels in Medicine and Pharmacy. \/\/ CRC Press, Boca Raton, FL. \u2013 1986. \u2013 Vol. 1. \u2013 P. 1-27.<br \/>\n10. Peppas N.A., Khare A.R. Preparation, structure and diffusional behavior of hydrogels in controlled release. \/\/ Adv. Drug Del. Rev. \u20131993. \u2013 11. \u2013 P. 1-35.<br \/>\n11. Flory P.J., Rehner J. Statistical mechanics of cross-linked polymer networks. II. Swelling. \/\/ J. Chem. Phys. \u2013 1943. \u2013 11. \u2013 P. 521-526.<br \/>\n12. Flory P.J. Statistical mechanics of swelling of network structures. \/\/ J. Chem. Phys. \u2013 1950. \u2013 18. \u2013 P. 108-111.<br \/>\n13. Peppas N.A. Hydrogels of poly(vinyl alcohol) and its copolymers, in: N.A. Peppas (Ed.), Hydrogels in Medicine and Pharmacy. \/\/ CRC Press, Boca Raton, FL. \u2013 1986. \u2013Vol. 2. \u2013 P. 1-48.<br \/>\n14. Stauffer S.R., Peppas N.A. Poly(vinyl alcohol) hydrogels prepared by freezing\u2013thawing cyclic processing. \/\/ Polymer.\u2013 1992. \u2013 33. \u2013 P. 3932-3936.<br \/>\n15. Mehrdad Hamidi, Amir Azadi, Pedram Rafiei. Hydrogel nanoparticles in drug delivery. \/\/ Advanced Drug Delivery Reviews. \u2013 2008. \u2013 60. \u2013 P. 1638-1649.<br \/>\n16. Coviello T., Matricardi P., Marianecci C., Alhaique F. Polysaccharide hydrogels for modified release formulations. \/\/ J. Control. Release. \u2013 2007. \u2013 119. \u2013 P. 5-24.<br \/>\n17. Lin C.C., Metters A.T. Hydrogels in controlled release formulations: network design and mathematical modeling. \/\/ Adv. Drug Deliv. Rev. \u2013 2006. \u2013 58. \u2013 P. 1379-1408.<br \/>\n18. Peppas N.A., Bures P., Leobandung W., Ichikawa H. Hydrogels in pharmaceutical formulations. \/\/ Eur. J. Pharm. Biopharm. \u2013 2000. \u2013 50. \u2013 P. 27-46.<br \/>\n19. Hennink W.E., van Nostrum C.F. Novel crosslinking methods to design hydro gels. \/\/ Adv. Drug Deliv. Rev. \u2013 2002. \u2013 54. \u2013 P. 13-36.<br \/>\n20. Hakkarainen B., Fujita K., Immel S., Kenne L., Sandstrom C. 1H-NMR studies on the hydrogen-bonding network in mono-altro-\uf062-cyclodextrin and its complex with adamantane-1-carboxylic acid. \/\/ Carbohydr Res. \u2013 2005. \u2013 340. \u2013 P. 1539-1545.<br \/>\n21. Alvarez Lorenzo C., Rosa dos Santos J.F., Sosnik A., Torres Labandeira J.J., Concheiro A. Hydrogels with cyclodextrins as highly versatile drug delivery systems. &#8211; In: Hanbook of Hydrogels: Properties, Preparation &amp; Applications, D.B. Stein Ed., Nova Science Publishers. \u2013 New York, 2009. \u2013 P. 1-42.<br \/>\n22. Bibby D.C., Davies N.M., Tucker I.G. Mechanisms by which cyclodextrins modify drug release from polymeric drug delivery systems. \/\/ Int. J. Pharm. \u2013 2000. \u2013 197. \u2013 P. 1-11.<br \/>\n23. Babu R.J., Dayal P., Singh M. Effect of cyclodextrins on the complexation and nasal permeation of melatonin. \/\/ Drug Deliv. \u2013 2008. \u2013 15. \u2013 P. 381-388.<br \/>\n24. Garcia-Gonzalez N., Kellaway I.W., Blanco-Fuente H., Anguiano-Igea S., Delgado-Charro B., Otero-Espi- nar F.J., Blanco-Mendez J. Influence of \uf062-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels. \/\/ Int. J. Pharm. \u2013 1993. \u2013100. \u2013 P. 25-31.<br \/>\n25. Tonelli A.E. Nanostructuring and functionalizing polymers with cyclodextrins. \/\/ Polymer. \u2013 2008. \u2013 49. \u2013 P. 1725-1736.<br \/>\n26. Nogueiras-Nieto L., Alvarez-Lorenzo C., Sandez-Macho I., Concheiro A., Otero-Espinar F.J. Hydrosoluble cyclodextrin\/ poloxamer polypseudorotaxanes at the air\/water interface, in bulk solution, and in the gel state. \/\/ J. Phys. Chem. B. \u2013 2009. \u2013 113. \u2013 P. 2773-2782.<br \/>\n27. Rodriguez-Tenreiro C., Alvarez-Lorenzo C., Rodriguez-Perez A., Concheiro A., Torres-Labandei- ra J.J. Estradiol sustained release from high affinity cyclodextrin hydrogels. \/\/ Eur. J. Pharm. Biopharm. \u2013 2007. \u2013 66. \u2013 P. 55-62.<br \/>\n28. Loftsson T. and Duchene D. Historical perspective. Cyclodextrins and their pharmaceutical applications. \/\/ Int. J. Pharm. \u2013 2007. \u2013 329. \u2013 P. 1-11.<br \/>\n29. Derakhshandeh K., Erfan M., Dadashzadeh S. Encapsulation of 9- nitrocamptothecin, a novel anticancer drug, in biodegradable nanoparticles: factorial design, characterization and release kinetics. \/\/ Eur. J. Pharm. Biopharm. \u2013 2007. \u2013 66(1). \u2013 P. 34-41.<br \/>\n30. Kumar P.S., et al. Influence of microencapsulation method and peptide loading on formulation of poly(lactide-co-glycolide) insulin nanoparticles. \/\/ Pharmazie. \u2013 2006. \u2013 61(7). \u2013 P. 613-617.<br \/>\n31. Budhian A., Siegel S.J., Winey K.I. Production of haloperidol-loaded PLGA nanoparticles for extended controlled drug release of haloperidol. \/\/ J. Microencapsul. \u2013 2005. \u2013 22(7). \u2013 P. 773-785.<br \/>\n32. Mittal G., et al. Estradiol loaded PLGA nanoparticles for oral administration: effect of polymer molecular weight and copolymer composition on release behavior in vitro and in vivo. \/\/ J. Control. Release. \u2013 2007. \u2013 119(1). \u2013 P. 77-85.<br \/>\n33. Atherden L.M. Studies with glycyrrhetic acid; inhibition of metabolism of steroids in vitro. \/\/ Biochem. J. \u2013 1958. \u2013 69(1). \u2013 P. 75-78.<br \/>\n34. Sarmento B., et al. Alginate\/chitosan nanoparticles are effective for oral insulin delivery. \/\/ Pharm. Res. \u2013 2007. \u2013 24(12). \u2013 P. 2198-2206.<br \/>\n35. De Campos A.M., Sanchez A., Alonso M.J. Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A. \/\/ Int. J. Pharm. \u2013 2001. \u2013 224(1\u20132). \u2013 P. 159-168.<br \/>\n36. Bajpai A.K., Choubey J. Design of gelatin nanoparticles as swelling controlled delivery system for chloroquine phosphate. \/\/ J. Mater. Sci. Mater. Med. \u2013 2006. \u2013 17(4). \u2013 P. 345-358.<br \/>\n37. Guo J.H., Cooklock K.M. Bioadhesive polymer buccal patches for buprenorphine controlled delivery: solubility consideration. \/\/ Drug. Dev. Ind. Pharm. \u2013 1995. \u2013 21. \u2013 P. 2013-2019.<br \/>\n38. Samy E.M., Safwat S.M. In vitro release of anti-inflammatory drugs with \uf062-cyclodextrin from hydrophilic gel bases. \/\/ STP Pharma. Sci. \u2013 1994. \u2013 4. \u2013 P. 458-465.<br \/>\n39. Villar-Lopez M.E., Nieto-Reyes L., Anguiano-Igea S., Otero- Espinar F.J., Blanco-Mendez J. Formulation of triamcinolone acetonide pellets suitable for coating and colon targeting. \/\/ Int. J. Pharm. \u2013 1999. \u2013 179. \u2013 P. 229-235.<br \/>\n40. Giunchedi P., Maggi L., La Manna A., Conte U. Modification of the dissolution behaviour of a water-insoluble drug, naftazone, for zero-order release matrix preparation. \u2013 1994.<br \/>\n41. Song C.X., Labhasetwar V., Levy R.J. Controlled release of U-86983 from double-layer biodegradable matrices: effect of additives on release mechanism and kinetics. \/\/ J. Pharm. Pharmacol. \u2013 1997. \u2013 46. \u2013 P. 476-480.<br \/>\n42. Davies N.M., Bary A.R., Tucker I.G. Use of a poorly soluble complex of pilocarpine with \uf062-cyclodextrin to control release from ophthalmic inserts. Proceedings of the International Symposium on the Controlled Release of Bioactive Material. \/\/ Kyoto. \u20131996. \u2013 23. \u2013P. 719-720.<br \/>\n43. Szejtli J. Cyclodextrin Technology. \u2013 Kluwer Academic, Dordrecht, 1988.<br \/>\n44. Sreenivasan K. On the restriction of the release of water-soluble component from polyvinyl alcohol film by blending b-cyclodextrin. \/\/ J. Appl. Polym. Sci. \u2013 1997. \u2013 65. \u2013 P. 1829-1832.<br \/>\n45. Filipovic-Grcic J., Becirevic-Lacan M., Skalko N., Jalsenjak I. Chitosan microspheres of nifedipine and nifedipinecyclodextrin inclusion complexes. \/\/ Int. J. Pharm. \u2013 1996. \u2013 135. \u2013 P. 183-190.<br \/>\n46. Marzouqi A.H.A., Shehatta I., Jobe B. and Dowai- dar A. Phase solubility and inclusion complex of Itraconazole with \uf062-cyclodextrin using supercritical carbon dioxide. \/\/ J. Pharm. Sci. \u2013 2006. \u2013 95(2). \u2013 P. 292-304.<br \/>\n47. Wang L., Jiang X., Xu W. and Li C. Complexation of Tanshinone IIA with 2-hydroxypropyl-\uf062-cyclodextrin: Effect on aqueous solubility, dissolution rate, and intestinal absorption behavior in rats. \/\/ Int. J. Pharm. \u2013 2007. \u2013 341(1-2). \u2013 P. 58-67.<br \/>\n48. Marques H.M.C., Hadgraft J. and Kellaway I.W. Studies of cyclodextrin inclusion complexes. I. The Salbutamol-cyclodextrin complex as studied by phase solubility and DSC. \/\/ Int. J. Pharm. \u2013 1990. \u2013 63(3). \u2013 P. 259-266.<br \/>\n49. Tayade P.T. and Vavia P.R. Inclusion complexes of Ketoprofen with \u0432 cyclodextrins: Oral pharmacokinetics of Ketoprofen in human. \/\/ Indian J. Pharm. Sci. \u2013 2006. \u2013 68(2). \u2013 P. 164-170.<br \/>\n50. Maestrelli F., Rodriguez M.L.G., Rabasco A.M. and Mura P. Preparation and characterisation of liposomes encapsulating Ketoprofen\u2013cyclodextrin complexes for transdermal drug delivery. \/\/ Int. J. Pharm. \u2013 2005. \u2013 298(1). \u2013 P. 55-67.<br \/>\n51. Sinha V.R., Anitha R., Ghosh S., Nanda A. and Kumria R. Complexation of Celecoxib with \uf062-cyclodextrin: Characterization of the interaction in solution and in solid state. \/\/ J. Pharm. Sci. \u2013 2005. \u2013 94(3). \u2013 P. 676-687.<br \/>\n52. Rao B.P., Sarasija S. and Narendra C. Physicochemical characterization of Hydroxypropyl-\uf062-cyclodextrin complexes of Rifampicin for improved anti-tubercular activity and stability. \/\/ Indian Drugs. \u2013 2006. \u2013 43(8). \u2013 P. 679-682.<br \/>\n53. Scalia S., Tursilli R., Sala N. and Iannuccelli V. Encapsulation in lipospheres of the complex between butyl methoxydibenzoylmethane and hydroxypropyl-\uf062-cyclodextrin. \/\/ Int. J. Pharm. \u2013 2006. \u2013 320(1-2). \u2013 P. 79-85.<br \/>\n54. Baboota S., Dhaliwal M., Kohli K. and Ali J. Inclusion complexation of Rofecoxib with dimethyl Beta-cyclodextrin. \/\/ Indian J. Pharm. Sci. \u2013 2005. \u2013 67(2). \u2013 P. 226-229.<br \/>\n55. Manosroi J., Apriyani M.G., Foe K. and Manosroi A. Enhancement of the release of Azelaic acid through the synthetic membranes by inclusion complex formation with hydroxypropyl-\uf062-cyclodextrin. \/\/ Int. J. Pharm. \u2013 2005. \u2013 293(1-2). \u2013 P. 235-240.<br \/>\n56. Duchene D., Vaution C. and Glomot F. Cyclodextrin, Their Value in pharmaceutical Technology. \/\/ Drug Dev. Ind. Pharm. \u20131988. \u2013 12(11-13). \u2013 P. 2193-2215.<br \/>\n57. Hassan M.A., Suleiman M.S. and Najib N.M. Improvement of the in vitro dissolution characteristics of Famotidine by inclusion in \uf062-cyclodextrin. \/\/ Int. J. Pharm. \u2013 1989. \u2013 58(1). \u2013 P. 19-24.<br \/>\n58. Erden N. and Celebi N. A study of the inclusion complex of Naproxen with \uf062-cyclodextrin. \/\/ Int. J. Pharm. \u2013 1988. \u2013 48(1-3). \u2013 P. 83-89.<br \/>\n59. Jadhav G.S. and Vavia P.R. Physicochemical, in silico and in vivo evaluation of a Danazol\u2013\uf062-cyclodextrin complex. \/\/ Int. J. Pharm. \u2013 2008. \u2013 352(1-2). \u2013 P. 5-16.<br \/>\n60. Bencini M., Ranucci E., Ferruti P., Trotta F., Donali-sio E., Cornagilia M., Lembo D. and Cavalli R. Preparation and in vitro evaluation of the antiviral activity of the Acyclovir complex of a \uf062-cyclodextrin\/poly(amidoamine) copolymer. \/\/ J. Controlled Release. \u2013 2008. \u2013 126(1). \u2013 P. 17-25.<br \/>\n61. Erden N. and Celebi N. A study of the inclusion complex of Naproxen with \uf062-cyclodextrin. \/\/ Int. J. Pharm. \u2013 1988. \u2013 48(1-3). \u2013 P. 83-89.<br \/>\n62. Chun I.K. and Yun D.S. Inclusion complexation of Hydrocortisone butyrate with cyclodextrins and dimethyl-\uf062-cyclodextrin in aqueous solution and in solid state. \/\/ Int. J. Pharm. \u20131993. \u2013 96(1-3). \u2013 P. 91-103.<br \/>\n63. Otero-Esppinar F.J., Igea A.N., Gonzalez N.G., Jato V.J.L. and Mendez J.B. Interaction of Naproxen with \uf062-cyclodextrin in solution and in the solid state. \/\/ Int. J. Pharm. \u2013 1992. \u2013 79(2). \u2013 P. 149-157.<br \/>\n64. Lin S.Y. and Kao Y.H. Solid particulates of drug-\uf062-cyclodextrin inclusion complexes directly prepared by a spray-drying technique. \/\/ Int. J. Pharm. \u2013 1989. \u2013 56(3). \u2013 P. 249-259.<br \/>\n65. Bekers O., Uijtendaal E.V., Beijnen J.H., Bult A. and Underberg W.J.M. Cyclodextrins in the pharmaceutical field. \/\/ Drug Dev. Ind. Pharm. \u2013 1991. \u201317(11). \u2013 P. 1503-1549.<br \/>\n66. Aithal K.S., Udupa N. and Sreenivassan K.K. Physicochemical properties of drug-cyclodextrin complexes. \/\/ Indian Drugs. \u2013 1995. \u2013 32(7). \u2013 P. 293-305.<br \/>\n67. Doijad R.C., Kanakal M.M. and Manvi F.V. Effect of processing variables on dissolution and solubility of Piroxicam: Hydroxypropyl-\uf062-cyclodextrin inclusion complexes. \/\/ Indian J. Pharm. Sci. \u2013 2007. \u2013 69(2). \u2013 P. 323-326.<br \/>\n68. Tomren M.A., Masson M., Loftsson T. and Tonne- sen H.H. Studies on curcumin and curcuminoids XXXI. Symmetric and asymmetric curcuminoids: Stability, activity and complexation with cyclodextrin. \/\/ Int. J. Pharm. \u2013 2007. \u2013 338(1-2). \u2013 P. 27-34.<br \/>\n69. RiBeiro L.S.S., Falcao A.C., Patricio J.A.B., Ferrei- ra D.C. and Veiga. F.J.B. Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimize the oral bioavailability of Vinpocetine. \/\/ J. Pharm. Sci. \u2013 2007. \u2013 96(8). \u2013 P. 2018-2028.<br \/>\n70. Lin S.Z., Wouessidjewe D., Poelman M. and Duche- ne D. Indomethacin and cyclodextrin complexes. \/\/ Int. J. Pharm. \u2013 1991. \u2013 69(3). \u2013 P. 211-219.<br \/>\n71. Tenjarla S., Puranajoti P., Kasina R. and Mandal T. Preparation, characterization and evaluation of Miconazole-Cyclodextrin complexes for improved oral and topical delivery. \/\/ J. Pharm. Sci. \u2013 1998. \u2013 87(4). \u2013 P. 425-429.<br \/>\n72. Uekama K., Fujinaga T., Hirayama F., Otagiri M., Yamasali M., Seo H., Hasimoto T. and Tsuruoka T. Improvement of the oral bioavailability of digitalis glycosides by cyclodextrin complexation. \/\/ J. Pharm. Sci. \u2013 1983. \u2013 72(11). \u2013 P. 1338-1341.<br \/>\n73. Smulevich G., Feis A., Mazzi G. and Vincieri F.F. Inclusion complex formation of 1,8-dihydroxyanthraquinone with cyclodextrins in aqueous solution and in solid state. \/\/ J. Pharm. Sci. \u2013 1988. \u2013 77(6). \u2013 P. 523-526.<br \/>\n74. Xiang T.X. and Andersoon B.D. Inclusion complexes of purine nucleosides with cyclodextrins: II. Investigation of inclusion complex geometry and cavity microenvironment. \/\/ Int. J. Pharm. \u2013 1990. \u2013 59(1). \u2013 P. 45-55.<br \/>\n75. Martinez A.G., Montoro T., Vinas M.H. and Tarda- jos G. Complexation and chiral drug recognition of an amphiphilic phenothiazine derivative with \uf062-cyclodextrin. \/\/ J. Pharm. Sci. \u2013 2008. \u2013 97(4). \u2013 P. 1484-1498.<br \/>\n76. Uekama K., Hirayama F., Otagiri M. and Yamasa- ki M. Inclusion complexations of steroid hormones with cyclodextrins in water and in solid phase. \/\/ Int. J. Pharm. \u2013 1982. \u2013 10(1). \u2013 P. 1-15.<br \/>\n77. Beni S., Szakacs Z., Csernak O., Barcza L. and Nos- zal B. Cyclodextrin\/Imatinib complexation: Binding mode and charge dependent stabilities. \/\/ Eur. J. Pharm. Sci. \u2013 2007. \u2013 30(2). \u2013 P. 167-174.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/doi.org\/10.15407\/polymerj.37.04.330 Polymer hydrogels based on cyclodextrins as carriers for drugs: synthesis and physicochemical properties \u00a0 L.A. Orel, S.V. Riabov, L.V. Kobrina, L.A. Goncharenko &nbsp; Institute of Macromolecular Chemistry the NAS of Ukraine 48, Kharkivske shose, Kyiv, 02160, Ukraine &nbsp; Polym. J., 2015, 37, no. 4: 330-340. &nbsp; Section: Review. &nbsp; Language: Ukrainian. &nbsp; Abstract: In [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1954"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=1954"}],"version-history":[{"count":2,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1954\/revisions"}],"predecessor-version":[{"id":2186,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/1954\/revisions\/2186"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=1954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}