{"id":2149,"date":"2018-02-07T17:11:48","date_gmt":"2018-02-07T14:11:48","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=2149"},"modified":"2018-02-07T17:11:48","modified_gmt":"2018-02-07T14:11:48","slug":"2014-3-12","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2014-3-12\/","title":{"rendered":"2014 (3) 12"},"content":{"rendered":"<p><strong>Efficiency research the of the sugar-containing segmented polyurethane elastomers with fragments of biose of lactose modified by hydrazide of isonicotinic acid <\/strong><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<p><strong><em>R.A. Rozhnova, I.B. Demchenko, I.I. Gladir, N.A. Galatenko <\/em><\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>Institute of Macromolecular Chemistry of NASc of Ukraine<\/p>\n<p>48 Kharkivske shose, Kyiv, 02160, Ukraine<\/p>\n<p>&nbsp;<\/p>\n<p>Polym. J., 2014, <strong>36<\/strong>, no. 3: 302-308.<\/p>\n<p>&nbsp;<\/p>\n<p>Section: Medical polymers.<\/p>\n<p>&nbsp;<\/p>\n<p>Language: Ukrainian.<\/p>\n<p>&nbsp;<\/p>\n<p>Abstract:<\/p>\n<p><em>The sugar-containing segmented polyurethane elastomers (SPE) on the basis of an isocyanate prepolimer (TDI 80\/20, POPG-1000), the extender of a macrochain of a mannitol (M) and izonicotinyl hydrazone D-lactoses (dGINA), taken in various molar ratios dGINA are synthesized: M = 1: 0; dGINA: M =7: 1; dGINA : M = 1: 1 . Into structure of synthesized SPE it was entered dGINA in number of 4 mas. % and it was investigated drug release by spectrophotometry. It is established that the increase in quantity of hydrophilic fragments in structure of the polymeric carrier promotes release izonicotinyl hydrazone D-lactoses in the conditions of in vitro. Quantity released dGINA during 49 days of 23,06<\/em><strong>\u2013<\/strong><em>23,58 %. Biocompatibility the sugar-containing segmented polyurethane elastomers that contain in the structure izonicotinyl hydrazone D-lactoses at implantation of samples by an experimental animals for 14 days, 1 and 3 months is investigated. <\/em><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Keywords:<\/strong> the segmented polyurethane elastomers, isoniazid, disaccharides, drug release, biocompatibility.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Efficiency research the of the sugar-containing segmented polyurethane elastomers with fragments of biose of lactose modified by hydrazide of isonicotinic acid \u00a0 R.A. Rozhnova, I.B. Demchenko, I.I. Gladir, N.A. Galatenko &nbsp; Institute of Macromolecular Chemistry of NASc of Ukraine 48 Kharkivske shose, Kyiv, 02160, Ukraine &nbsp; Polym. J., 2014, 36, no. 3: 302-308. &nbsp; Section: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/2149"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=2149"}],"version-history":[{"count":1,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/2149\/revisions"}],"predecessor-version":[{"id":2150,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/2149\/revisions\/2150"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=2149"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}