{"id":2608,"date":"2019-03-20T12:10:57","date_gmt":"2019-03-20T09:10:57","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=2608"},"modified":"2019-04-03T11:41:38","modified_gmt":"2019-04-03T08:41:38","slug":"2019-1-7","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2019-1-7\/","title":{"rendered":"2019 (1) 7"},"content":{"rendered":"

https:\/\/doi.org\/10.15407\/polymerj.41.01.058<\/a><\/p>\n

Polyurethanes synthesized on the basis of di- and polyisocyanate filled with doxorubicin: a study of the structure and properties <\/strong><\/p>\n

\u00a0<\/em><\/strong><\/p>\n

    \n
  1. A. Lukashevich, G. A. Kozlova <\/em><\/strong><\/li>\n<\/ol>\n

     <\/p>\n

    Institute of Macromolecular Chemistry NAS of Ukraine<\/p>\n

    48, Kharkivske shose, Kyiv, 02160, Ukraine<\/p>\n

     <\/p>\n

    Polym. J., 2019, 4<\/strong>1<\/strong>, no. 1: 58-62<\/p>\n

     <\/p>\n

    Section: Medical polymers.<\/p>\n

     <\/p>\n

    Language: Ukrainian.<\/p>\n

     <\/p>\n

    Abstract:<\/p>\n

     <\/p>\n

    \u00a0<\/em><\/p>\n

    In this paper, the structure and specific properties of polyurethane polymeric composite materials based on di- and polyisocyanate are investigated. According to IR spectroscopic data, changes in the polymer structure are shown due to redistribution and the formation of new intermolecular hydrogen bonds. Indicators of tensile strength and relative elongation in PU of a branched structure of control samples and samples with doxorubicin depend on the ratio of TDI \/ HDT-90. According to the data of physical and mechanical studies, it has been revealed that polymeric materials that contain in their composition di- and polyisocyanate filled with doxorubicin can be used to create soft tissue implants with a prolonged therapeutic effect.<\/em><\/p>\n

    \u00a0<\/strong><\/p>\n

    Keywords:<\/strong> polyurethanes (PU), implant, structural modification, prolonged action, doxorubicin.<\/p>\n

     <\/p>\n

    References <\/strong><\/p>\n

      \n
    1. Resiak I., Rokicki G.<\/em> Modyfikowane poliuretany do zastosowa\u0441 medycznych. Polimery, 2000, no. 9: 592\u2013602. https:\/\/doi.org\/10.14314\/polimery.2000.592<\/u><\/li>\n
    2. J. Brzeska, H. Janik, M. Kowalczuk, and M. Rutkowska<\/em>, \u201cPreliminary investigations of biocompatibility of polyurethanes based on synthetic polyhydroxybutyrate\u201d, Engineering of Biomaterials, 2011, 106\u2013108 (XIV): 65\u201372.<\/li>\n
    3. Beck R. A., Truss R.W.<\/em> Effect of chemical structure on the wear behavior of polyurethane-urea elastomers.Wear, July 1998, 218<\/strong>(2):145\u2013152. https:\/\/doi.org\/10.1016\/S0043-1648(98)00219-1<\/u><\/li>\n
    4. Gorbunova N.A., Galatenko N.A., Rojnova R.A., Kuksin A.N.<\/em> Novye nanostrukturirovannye bioaktivnye kompozicionnye materialy medicinskogo naznacheniya. International Scientific and Technical Conference. \u201cPolimernye kompozity i tribologiya\u201d, 22\u201325 06.2009. Belarus, Gomel, 2009: 62.<\/li>\n
    5. Malanchuk V.A., Astapenko E.A., Galatenko N.A., Rojnova R.A.<\/em> Rezultaty issledovaniya fiziko-mehanicheskih svoystv biodegradiruemogo polimera, ispolzuemogo v rekonstruktivno-vosstano-vitelnoy hirurgii kostey chelyustno-licevoy oblasti. Vi\u2019snik problem bi\u2019ologi\u2019i\u2018 i\u2019 medicini, 2013, 2, no. 100: 304\u2013308.<\/li>\n
    6. Kovaleva I.A., Morozova N.I., Zubov P.I.<\/em> Vliyanie strukturoobrazovaniya v rastvorah poliuretana na svoystva plenok. Vysokomol. soed. 1986, 28<\/strong>, no. 4: 753\u2013757.<\/li>\n
    7. Pat. No 212763J Poland. \u201cBiodegradable polyurethanes and the way of their production\u201d. Brzeska, P. Dacko, H. Janik, M. Kowalczuk, and M. Rutkowska, Publ. 16.06. 2012, (in Polish).<\/li>\n
    8. Gorbatenko V.I.<\/em> Izocianaty. Metody sinteza i fiziko-himicheskie svoystva alkil-, aril, i geterilizocianatov. K.: Naukova dumka, 1987: 444<\/li>\n
    9. Elbl L., Vasova I., Navratil M., Tomaskova I., Jedlicka F., Chaloupka V., Mayer J., Vorlicek J.<\/em> Late cardiotoxicity in patients with malignant lymphoma treated with doxorubicin chemotherapy. J. Vnitr Lek. 2006, 52<\/strong>, no. 4: 328\u201338.<\/li>\n
    10. Subrata M., Darren M.<\/em> Hydrolytic degradation of segmented polyurethane copolymers for biomedical applications. Polymer. Degrad. Stabil. 2012, 97<\/strong>, no. 8: 1553\u20131561. https:\/\/doi.org\/10.1016\/j.polymdegradstab.2012.04.008<\/u><\/li>\n
    11. Prech E., Byulmann F., Affolter K.<\/em> Opredelenie stroeniya organicheskih soedineniy. M.: Mir; BINOM. Laboratoriya znaniy, 2006: 55.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

      https:\/\/doi.org\/10.15407\/polymerj.41.01.058 Polyurethanes synthesized on the basis of di- and polyisocyanate filled with doxorubicin: a study of the structure and properties \u00a0 A. Lukashevich, G. A. Kozlova   Institute of Macromolecular Chemistry NAS of Ukraine 48, Kharkivske shose, Kyiv, 02160, Ukraine   Polym. J., 2019, 41, no. 1: 58-62   Section: Medical polymers.   Language: Ukrainian. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/2608"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=2608"}],"version-history":[{"count":2,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/2608\/revisions"}],"predecessor-version":[{"id":2620,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/2608\/revisions\/2620"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=2608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}