{"id":3000,"date":"2020-12-03T16:33:11","date_gmt":"2020-12-03T13:33:11","guid":{"rendered":"http:\/\/polymerjournal.kiev.ua\/en\/?page_id=3000"},"modified":"2020-12-03T16:33:11","modified_gmt":"2020-12-03T13:33:11","slug":"2020-4-3","status":"publish","type":"page","link":"http:\/\/polymerjournal.kiev.ua\/en\/2020-4-3\/","title":{"rendered":"2020 (4) 3"},"content":{"rendered":"

https:\/\/doi.org\/10.15407\/polymerj.42.04.262
\nSTUDY THE STRUCTURE AND THERMAL PROPERTIES OF CARBOXYMETHYLATED-\u03b2-CYCLODEXTRIN INCLUSION COMPLEX WITH BIFONAZOLE<\/strong>
\nL. Kobrina<\/strong>,
\nInstitute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
\nORCID: 0000-0001-6801-0801
\ne-mail: kobrina.larisa@gmail.com<\/a>
\nS. Sinelnikov<\/strong>,
\nInstitute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
\nV. Shtompel<\/strong>,
\nInstitute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
\nE-mail: vishtomp@bigmir.net<\/a>
\nD. Bandurina<\/strong>,
\nInstitute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
\nORCID: 0000-0003-1535-2888
\nS. Riabov<\/strong>,
\nInstitute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
\nORCID: 0000-0001-9430-7270
\nE-mail: sergii.riabov@gmail.com<\/a>
\nPolym. J., 2020, 42, no. 4: 262-268.
\nSection: Structure and properties.
\nLanguage: Ukrainian.<\/p>\n

\nAbstract:
\nRecently, many technological methods of enhancing the solubility and dissolution characteristics of poorly water soluble drugs have been reported in the literature. \u0421yclodextrins are able to form water-soluble non-covalent inclusion complexes with many poorly soluble lipophilic drugs. The purpose of this study is to evaluate the possibility of interaction of the antifungal drug Bifonazole (BFZ) through complexation with carboxymethylated-\u03b2-cyclodextrin (\u041a\u041c-\u03b2-CD). Based on the data obtained, we can conclude that the presence of KM-\u03b2-CD improves solubilization of BFZ more than 50 times.<\/em><\/p>\n

\u041a\u0435\u0443words: cyclodextrins, solubility, poorly-water soluble drugs, bifonazole.<\/p>\n

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 <\/p>\n

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https:\/\/doi.org\/10.15407\/polymerj.42.04.262 STUDY THE STRUCTURE AND THERMAL PROPERTIES OF CARBOXYMETHYLATED-\u03b2-CYCLODEXTRIN INCLUSION COMPLEX WITH BIFONAZOLE L. Kobrina, Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine ORCID: 0000-0001-6801-0801 e-mail: kobrina.larisa@gmail.com S. Sinelnikov, Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine V. Shtompel, Institute of Macromolecular Chemistry NAS of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/3000"}],"collection":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=3000"}],"version-history":[{"count":1,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/3000\/revisions"}],"predecessor-version":[{"id":3001,"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/3000\/revisions\/3001"}],"wp:attachment":[{"href":"http:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=3000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}