2026 (1) 4
https://doi.org/10.15407/polymerj.48.01.030
SYNTHESIS AND INVESTIGATION OF MEDICAL-GRADE POLYURETHANE-UREA FOAMS INCORPORATING DECAMETOXIN
Serhii LISNIAK* (ORCID: 0009-0006-0165-0197)
Iryna GLADYR (ORCID: 0000-0002-6248-2709)
Galyna KOZLOVA (ORCID: 0000-0001-8114-4812)
Valeriy DENYSENKO (ORCID: 0000-0003-3675-769X)
Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, 48, Kharkivske Highway, Kyiv, Ukraine, 02155
*Corresponding author.
E-mail: sergiilisnyak@gmail.com
Polimernyi Zhurnal, 2026, 48, no. 1: 30-38
Section: Medical polymers
Language: Ukrainian.
Abstract
The aim of this study was to synthesize and investigate medical-grade polyurethane-urea foams (PUUFs) with immobilized decamethoxin (DCM). The PUUFs were prepared using mixtures of macrodiisocyanates MDI(I) and MDI(II) at molar ratios of 1:1, 2:1, and 3:1, followed by the addition of 1 wt.% DCM. A comprehensive characterization was performed, using physicomechanical testing, differential scanning calorimetry (DSC), and FTIR spectroscopy. It was established that the MDI(I):MDI(II) ratio of 1:1 provided the optimal tensile strength (σ = 0.43 MPa), elongation at break (ε = 360.3 %), and adhesive strength (τ = 6.30 MPa). The incorporation of decamethoxin led to a decrease in tensile strength and elasticity, which is attributed to structural rearrangements within the polymer matrix. FTIR analysis showed changes in the intensities of NH and C=O absorption bands involved in hydrogen bonding, with no new bands appearing, indicating that DCM immobilization occurs mainly through physical interactions. DSC results showed changes in the glass transition temperature (Tg) and ΔCp values, indicating alterations in segmental mobility and intermolecular interactions when DCM is present. The obtained materials exhibited a single-phase structure. Despite a moderate decrease in mechanical properties, the DCM-containing compositions maintained sufficient performance characteristics and can be considered promising antimicrobial polyurethane systems for developing medical adhesives and materials with prolonged local therapeutic effects.
Keywords: polyurethane, polyurethane-urea foams, decamethoxin, аntimicrobial polymer materials, medical adhesives.
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