{"id":4260,"date":"2025-05-22T14:31:09","date_gmt":"2025-05-22T11:31:09","guid":{"rendered":"https:\/\/polymerjournal.kiev.ua\/?page_id=4260"},"modified":"2025-05-22T14:31:12","modified_gmt":"2025-05-22T11:31:12","slug":"2025-1-4","status":"publish","type":"page","link":"https:\/\/polymerjournal.kiev.ua\/en\/2025-1-4\/","title":{"rendered":"2025 (1) 4"},"content":{"rendered":"

https:\/\/doi.org\/10.15407\/polymerj.47.01.030<\/a><\/p>\n

INVESTIGATION OF THE BIODEGRADATION OF POLYURETHANE-UREAS CONTAINING FRAGMENTS OF GRAFT COPOLYMER POLYVINYL ALCOHOL\u2013POLYETHYLENE GLYCOL IN THE STRUCTURE UNDER MODEL CONDITIONS OF THE INFLAMMATORY PROCESS<\/strong><\/p>\n

TETIANA VISLOHUZOVA<\/strong>1<\/sup>* (ORCID: 0000-0002-4071-4329), RITA ROZHNOVA<\/strong>1<\/sup>** (ORCID: 0000-0003-3284-3435), TETIANA KISELOVA<\/strong>1<\/sup> (ORCID: 0000-0001-5606-6904), GALYNA KOZLOVA<\/strong>1<\/sup> (ORCID: 0000-0001-8114-4812), LILIIA PALONA<\/strong>2<\/sup> (ORCID: 0009-0008-0358-4538)
\n1<\/sup>Institute of Macromolecular Chemistry of the NAS of Ukraine, 48, Kharkivske Shose, Kyiv, 02155, Ukraine
\n2<\/sup>National University of Kyiv-Mohyla Academy, 2, Skovorody Street, Kyiv 04070, Ukraine
\n*e-mail: rudenchyk@gmail.com<\/a>
\n**e-mail: rozhnovarita@gmail.com<\/a><\/p>\n

Polimernyi Zhurnal, 2025,\u00a047<\/strong>, no. 1: 30-38<\/p>\n

Section: Medical polymers.<\/p>\n

Language: English.<\/p>\n

Abstract:<\/strong><\/h3>\n

The aim of this study was to investigate the biodegradation capacity of hydrophilic polyurethane-ureas (PUUs) containing fragments of 4,4\u2032-diaminodiphenylmethane (DADPh) and a grafted copolymer polyvinyl alcohol\u2013polyethylene glycol (PVA\u2013PEG) in their structure under model conditions of the inflammatory process when in contact with blood. The biodegradation capability was evaluated by infrared (IR) spectroscopy, physical-mechanical testing, and differential scanning calorimetry (DSC) by monitoring changes in the structure, physical-mechanical, and thermophysical properties of the PUUs under the influence of the Fenton reagent over incubation periods of 1, 3, and 6 months. According to IR spectroscopy data, exposure to the Fenton reagent initiates an oxidative degradation process of the investigated PUUs, accompanied by the cleavage of specific chemical bonds, alterations in hydrogen bonding, and structural transformations of the polymer matrix. The physical-mechanical properties depend on the incubation duration in the Fenton reagent and change nonlinearly. After 6 months of incubation, compared to the control, an increase in strength and relative elongation at break was observed, which can be explained by the formation of new hydrogen bonds under the influence of the model medium. DSC results revealed that after incubation in the Fenton reagent, the PUU samples exhibited an increase in the glass transition temperature (Tg<\/sub>) and a jump in heat capacity (\u0394Cp<\/sub>) at the glass transition, indicating structural changes during the oxidative degradation process. Thus, the investigated materials demonstrate the process of oxidative biodegradation under the influence of a model medium. Therefore, PUUs containing fragments of the grafted copolymer PVA\u2013PEG in their structure represent a promising polymer matrix for temporary medical applications.<\/p>\n

<\/h3>\n

Keywords:<\/strong> polyurethane-urea, grafted copolymer polyvinyl alcohol\u2013polyethylene glycol, oxidative biodegradation, Fenton reagent.<\/p>\n

References<\/strong><\/h3>\n

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https:\/\/doi.org\/10.15407\/polymerj.47.01.030 INVESTIGATION OF THE BIODEGRADATION OF POLYURETHANE-UREAS CONTAINING FRAGMENTS OF GRAFT COPOLYMER POLYVINYL ALCOHOL\u2013POLYETHYLENE GLYCOL IN THE STRUCTURE UNDER MODEL CONDITIONS OF THE INFLAMMATORY PROCESS TETIANA VISLOHUZOVA1* (ORCID: 0000-0002-4071-4329), RITA ROZHNOVA1** (ORCID: 0000-0003-3284-3435), TETIANA KISELOVA1 (ORCID: 0000-0001-5606-6904), GALYNA KOZLOVA1 (ORCID: 0000-0001-8114-4812), LILIIA PALONA2 (ORCID: 0009-0008-0358-4538) 1Institute of Macromolecular Chemistry of the NAS of Ukraine, 48, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/4260"}],"collection":[{"href":"https:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/comments?post=4260"}],"version-history":[{"count":1,"href":"https:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/4260\/revisions"}],"predecessor-version":[{"id":4261,"href":"https:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/pages\/4260\/revisions\/4261"}],"wp:attachment":[{"href":"https:\/\/polymerjournal.kiev.ua\/en\/wp-json\/wp\/v2\/media?parent=4260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}