2014 (3) 12

Efficiency research the of the sugar-containing segmented polyurethane elastomers with fragments of biose of lactose modified by hydrazide of isonicotinic acid

R.A. Rozhnova, I.B. Demchenko, I.I. Gladir, N.A. Galatenko

Institute of Macromolecular Chemistry of NASc of Ukraine

48 Kharkivske shose, Kyiv, 02160, Ukraine

Polym. J., 2014, 36, no. 3: 302-308.

Section: Medical polymers.

Language: Ukrainian.

Abstract:

The sugar-containing segmented polyurethane elastomers (SPE) on the basis of an isocyanate prepolimer (TDI 80/20, POPG-1000), the extender of a macrochain of a mannitol (M) and izonicotinyl hydrazone D-lactoses (dGINA), taken in various molar ratios dGINA are synthesized: M = 1: 0; dGINA: M =7: 1; dGINA : M = 1: 1 . Into structure of synthesized SPE it was entered dGINA in number of 4 mas. % and it was investigated drug release by spectrophotometry. It is established that the increase in quantity of hydrophilic fragments in structure of the polymeric carrier promotes release izonicotinyl hydrazone D-lactoses in the conditions of in vitro. Quantity released dGINA during 49 days of 23,06–23,58 %. Biocompatibility the sugar-containing segmented polyurethane elastomers that contain in the structure izonicotinyl hydrazone D-lactoses at implantation of samples by an experimental animals for 14 days, 1 and 3 months is investigated.

Keywords: the segmented polyurethane elastomers, isoniazid, disaccharides, drug release, biocompatibility.