2014 (3) 13

Physico-cmemical study of silica modified by heparine for developing of new drug release systems

L.R. Azizova1, Т.V. Kulyk 1, B.B. Palianytsia 1, К. Lаszlо2, А. Menihard2

1Iнститут химии поверхности им. А.А. Чуйко NAS of Ukraine

17, General Naumov str., Kyiv, 03164, Ukraine

2Department of Physical Chemistry and Material Science, Budapest University of Technology and Economics

H-1521 Budapest, Hungary

Polym. J., 2014, 36, no. 3: 309-315.

Section: Medical polymers.

Language: Ukrainian.

Abstract:

The silica modified by heparine has been investigated using temperature programmed desorption mass spectrometry (TPD‑MS), IR‑spectroscopy, thermogravimetry and photon correlation spectroscopy methods. Stages and products of heparin thermolysis in the pristine state and adsorbed on the silica surface have been identified. SEM-images and the particle size distribution analysis showed that the modification of silica by heparin leads to deaggregation of silica particles, decrease of particles diameter and the narrower particle-size distribution. However, the main fraction of the particles remains in the form of aggregates with diameter between 50 and 500 nm.

Key words: heparine, fumed silica, temperature programmed desorption mass spectrometry (TPD‑MS), photon correlation spectroscopy, scanning electron microscopy.