2014 (3) 14

Invetstigathion of mechanism of antioxidant activity of albumin

G.S. Shapoval, O.S. Kruglyak, I.Ye. Myronyuk

Institute of Bioorganic Chemistry and Petrochemistry NAS of Ukraine

1, Murmanska str, Kyiv 02094, Ukraine

Polym. J., 2014, 36, no. 3: 316-321.

Section: Medical polymers.

Language: Russian.

Abstract:

Interaction of albumin and model amino acids with the electrochemically generated active forms of oxygen – hydroxylic radicals and peroxigen is investigated by the voltammetry method at molecular level. It is shown that albumin and number of amino acids, simulating amino acid residues on the surface of albumin globule, displayes both antiradical and antioxidant activities. The relative values of this activity are determined for the model amino acid. The assumptions about their contribution to total antioxidant activity of albumin are suggested.

Keywords: albumin, amino acids, antioxidant activity.