2018 (1) 5

The investigation of nanosystems branched polymer/nanogold in the region of conformational transition of a polymer matrix

V.A. Chumachenko, Yu.I. Harahuts, N.V. Kutsevol, N.P. Melnyk, O.M. Nadtoka

Taras Shevchenko National University of Kyiv, Department of Chemistry

60, Volodymyrska str., Kyiv, 01033, Ukraine, kutsevol@ukr.net

Polym. J., 2018, 40, no. 1: 36-40

Section: Structure and properties.

Language: Ukrainian.

Abstract:

Poly-N-isopropylacrylamide (PNIPAA) is a biocompatible thermosensitive polymer that is promising for using in nanobiotechnologies since this polymer has a phase transition temperature (LCST) in the physiological temperature range. LCST can be regulated by changing the hydrophilic-hydrophobic balance of the PNIPAA-containing macromolecule or by changing its structure. The incorporation of gold nanoparticles into PNIPAA polymer-nanocarrier is one of the modern approaches for the creation of new generation of drugs for photodynamic and photothermal antitumor therapy. The gold nanoparticles were synthesized in situ into polymeric matrix of branched star-shaped thermosensitive copolymer with dextran core and grafted poly-N-isopropylacrylamide chains (D-PNIPAA). Transmission electron microscopy has shown that gold nanoparticles had a spherical shape and a size of 5-10 nm. Dynamic light scattering was used for study D-PNIPAA/Au nanosystem in the region of the conformational transition of a polymer matrix. It was established that nanosystem D-PNIPAA/Au contained free nanoparticles of metals, as well as aggregates of polymer macromolecules with incorporated Au nanoparticles. The size of gold nanoparticles did not change in the studied temperature region.

Key words: branched polymer, Poly-N-isopropylacrylamide, LCST, conformational transition, Au nanoparticles.

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