2018 (4) 1

https://doi.org/10.15407/polymerj.40.04.216

Unsaturated esters and polymeric materials on their basis of medical applications

T.V. Rudenchyk, R.A. Rozhnova, N.A. Galatenko

Institute of Macromolecular Chemistry of NAS of Ukraine

48 Kharkivske shausse, Kyiv, 02160, Ukraine

Polym. J., 2018, 40, no. 4: 216-229.

Section: Review.

Language: Ukrainian.

Abstract:

The review is devoted to unsaturated esters with double bundles of fumaric acid, in particular to propylene fumarates, which are capable to reaction of copolymerization with the formation of biodegradable polymer materials as perspective polymeric matrices for release of substances drugs. Synthesis of propylene fumarates and polymers on their basis attracts the attention of many scientists of the world and is relevant. The methods of synthesis, purification, and also the influence of the choice of reagents, catalysts, inhibitors and reaction conditions on the final properties of propylene fumarates are presented. The creation of biopolymers on their basis with the use of different monomers, different methods of initiation, and application in medical practice has been demonstrated. It is shown that polymer materials based on propylene fumarates are biocompatible, capable to prolonged release of substances drugs, are capable to biodegradation, causing their applications without repeated surgical intervention for removal. They are perspective materials and are suitable for use as implantable materials in reconstructive surgery.

Keywords: poly(propylene fumarate), copolymerization, biodegradation, biocompatibility, orthopedics, osteogenesis.

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Надійшла до редакції 10 жовтня 2018 р.