2018 (4) 3
https://doi.org/10.15407/polymerj.40.04.240
Peculiarities of structural organization and antimicrobial activity of copper-containing nanocomposites
V.L. Demchenko, V.I. Shtompel, L.A. Goncharenko, S.M. Kobylinsky, S.V. Riabov
Institute of Macromolecular Chemistry NAS of Ukraine
48, Kharkivske shose, Kyiv, 02160, Ukraine
Polym. J., 2018, 40, no. 4: 240-245.
Section: Structure and properties.
Language: Ukrainian.
Abstract:
Metal-polymer nanocomposites possess unique characteristics and a wide range of applications (for the design of catalytic systems as well as in optoelectronics and nanophotonics). When the polymer matrices are filled with silver and copper nanoparticles, they acquire new valuable properties and can be used as effective antibacterial and antiviral drugs in medicine, pharmacology, and biochemistry. Such materials require a fundamental study of the structure, morphology and antimicrobial properties. The aim of this work is to study the features of the structural organization and antimicrobial activity (in relation to S. aureus and E. coli strains) of polymer films based on polyelectrolyte complexes and copper nanoparticles obtained by chemical and thermochemical reduction of copper ions in polyelectrolyte-metal complexes. The features of structural organization of copper-containing nanocomposites were studied by wide-angle X-ray diffraction on a DRON-4-07 diffractometer, the X-ray optical scheme of which was performed to “pass” primary beam radiation through samples. X-ray studies were carried out at T = 20 ± 2 °C in CuKa-radiation, monochromated with a Ni-filter. The antimicrobial activity was studied using reference strains of opportunistic bacteria Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 35218 as model of Gram-positive and Gram-negative bacteria by agar diffusion method on a solid Luria-Bertani nutrient medium. According to the results of the research, it was found out that the optimal conditions for the reductions of copper ions, namely, the duration of the chemical reduction process and its temperature are 2 hours and 170 °C, respectively as well as it was revealed that the obtained materials have high antimicrobial activity on the microorganisms tested (S. aureus and E. coli). In general, it is shown that antimicrobial activity against the test microorganisms are better for the nanocomposites obtained by the thermochemical reduction rather than chemical one.
Key words: polyelectrolyte complexes, polyelectrolyte–metal complexes, copper-containing nanocomposite, structure, antimicrobial activity.
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Надійшла до редакції 8 жовтня 2018р.