2018 (4) 4
https://doi.org/10.15407/polymerj.40.04.246
Double hydrophilic block copolymers containing poyacrylamide and polyacrilic acid
L.R. Kunitskaya1, Т.B. Zheltonozhskaya1, M. Destarac2, S. Mazieres2, L.M. Grishchenko1
1Taras Shevchenko National University of Kyiv
60, Volodymyrska str., Kyiv, 01033, Ukraine
2UMR CNRS 5623 Universite deToulouse
118, route de Narbonne, Toulouse Cedex 9, 31062, France
Polym. J., 2018, 40, no. 4: 246-253.
Section: Synthesis polymers.
Language: Ukrainian.
Abstract:
The synthesis of block copolymers with incompatible hydrophilic and hydrophobic blocks is one of the traditional approaches for creation of nanocontainers and nanoreactors. Opposing to this, amphiphilic block copolymers of another type are being developed in the Macromolecular Chemistry Department of Taras Shevchenko National University of Kyiv. They consist of hydrophilic blocks which are capable to cooperative interactions and form intramolecular polycomplexes (IntraPC). One of the perspective directions of IntraPC application is development of nanocontainers for target drugs delivery. So to use block copolymers forming IntraPC in nanotechnologies their synthesis techniques should be improved. This is necessary for obtaining strictly controlled molecular mass and molecular architecture. The “living” radical technique being developed for the late years makes it possible to obtain block copolymers with required molecular weight of blocks and narrow chain-length distribution. Reversible addition/fragmentation chain transfer (RAFT) and macromolecular design via the interchange of xanthates (MADIX) can be called as one of the most original and perspective types of «living» radical process. In the present work two series of asymmetric diblock copolymers PAAc-b-PAAm (DBC) and thriblock copolymers PAAm-b-PAAc-b-PAAm (TBC) consisting of PAAc blocks of constant block length (~10 kDа) and PAAm blocks with variable chain length were obtained using RAFT/MADIX technique. The morphology of the obtained block copolymers and the processes of their micelle formation in aqueous solutions were studied. It was shown that of PAA blocks which are “corona”-forming blocks, play the key role in the process of micelle formation and respond for the micelles stability. The existence of two morphological types of primary micelles which could be stipulated by the difference mechanism of their formation was found. The reasons for a simultaneous coexistence of different morphological types are discussed.
Key words: polyacrylamide, polyacrilic acid, micellar compositions, controled-living radical polymerization.
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Надійшла до редакції 22 жовтня 2018 р.