2019 (3) 4

https://doi.org/10.15407/polymerj.41.03.173

Investigation of the inclusion complex of carboxymethylated b-Cyclodextrin with Phenoxatiin

L.V. Kobrina1, V.V. Boyko1, S.V. Riabov1, S.I. Sinelnikov1, V.I. Bortnitskiy1, Daria Bandurina2, Oleg Moskalenko2

1Institute of Macromolecular Chemistry NAS of Ukraine

48, Kharkivske shose, Kyiv, 02160, Ukraine

2 Nikolai Gogol State University of Nizhyn

2, Grafska str., Nizhyn, Chernihivska Oblast, 16600, Ukraine

Polym. J., 2019, 41, no. 3: 173-178.

Section: Synthesis of polymers.

Language: Ukrainian.

Abstract:

Phenoxatiin (Phx.) is a substance that is structurally similar to dioxin – an extremely toxic reagent that does not decompose in the environment. Therefore, the study of inclusion complexes of cyclodextrins with Phx. and its derivatives is very relevant. The purpose of this work was to investigate the formation of a inclusion complex of Phx. with a new b-CD’s derivative, namely, carboxymethylated b-cyclodextrin. So, carboxymethylated b-cyclodextrin (KM-b-CD) was synthesized and identified. To prepare inclusion complex of KM-b-CD with Ph. the starting materials were separately dissolved in aqueous solutions, then mixed and held for 20 hours at 60 °C with occasional stirring. The obtained clear solution was evaporated and dried for two days. The resulting product was a white, odorless substance. The formation of the inclusion complex is confirmed by the methods of FTIR-spectroscopy and pyrolytic mass spectrometry. Using the Higuchi and Connors approach, the phase solubility of phenoxatiin was determined in the presence of KM-b-CD. The linear solubility dependence (AL-type) indicates to the stoichiometric composition of the complex prepared, namely, Phx. : KM-b-CD = 1:1. It was established that the stability constant (K) of the KM-b-CD complex with Phx. is equal to 3,8. For comparison, K for methyl-b-CD was 2,22 and for 2-hydroxypropyl b-CD reaches 2,76, correspondingly. So carboxymethylated b-cyclodextrin is more suitable for promoting solubilization of Phx. in water, than 2-hydroxypropyl-b-CD or methyl-b-CD as well.

Key words: carboxymethylated b-cyclodextrin, phenoxatiin, complex, solubility.

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