2019 (3) 7

https://doi.org/10.15407/polymerj.41.03.198

Study of the influence of the model biological environment on the structure and properties of polyurethane ureas with lysozyme, which contain fragments of copolymer of vinyl butyral, vinyl acetate and vinyl alcohol in the structure

K.V. Stashenko, T.V. Rudenchyk, R.A. Rozhnova, N.A. Galatenko, L.Yu. Nechaeva

Institute of Macromolecular Chemistry NAS of Ukraine

48, Kharkivske shose, Kyiv, 02160, Ukraine

Polym. J., 2019, 41, no. 3: 198-205.

Section: Medicine polymers.

Language: Ukrainian.

Abstract:

The influence of the model biological environment 199 (BS 199) on the structure and properties of composite materials with lysozyme on the basis of polyurethane-urea (PUU) with fragments copolymer poly-vinyl butyral, vinyl acetate with vinyl alcohol (PVB) has been studied. Infrared spectroscopic and physical-mechanical investigations of polyurethane urea with lysozyme have been performed, which predict the structure of fragments of PVB copolymer after incubation in a biological medium 199. It was established that under the influence of BS 199 biodegradation of the studied PUU and compositions with lysozyme on their basis is accompanied by the structuring of the polymer matrix by destroying and redistributing the network of intermolecular hydrogen bonds to form a more perfect physical interactions grid. The method of spectrophotometry has established that the developed composite materials are capable of prolonged release of an antibacterial preparation of lysozyme, that for the PUU, synthesized for the ratio of GMDA:PVB as 70:30 for 4 days is 75.0 %.

Key words: polyurethane urea, lysozyme, biodegradation, biological medium 199, release dynamics.

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