2019 (4) 7

Composite materials based on isocyanurate-containing polyurethane with a prolonged release of doxorubicin

S.A. Lukashevich, R.A. Rozhnova, G.A. Kozlova, L.Yu. Nechaeva

Institute of Macromolecular Chemistry NAS of Ukraine

48, Kharkivske shose, Kyiv, 02160, Ukraine; lsa2010new@ukr.net

Polym. J., 2019, 41, no. 4: 271-278.

Section: Medicine polymers.

Language: Ukrainian.

Abstract:

Based on polyoxypropylene glycol, TDI (2,4; 2,6-toluene diisocyanate), isocyanuraut HDT – 90 (2,4,6-triisocyanate (trishexamethylene) isocyanurate) and the lancinogluhydrazide adipic acid extender (ADH) for a different molar conjugate – dihydrazide of adipic acid for a different molar conjugate – dihydrazide of adipic acid (ADH), for a different molar conjugate – dihydrazide of adipic acid, for the same time, the adduct of the lancinoglu – dihydrazide of adipic acid ADH for a different molar conjugate – dihydrazide of adipic acid for a different molar ratio of adipic acid – ADH for a different molar ratio — adidic acid for the same molar – dihydride bond of adipic acid for the same time new polymeric materials with isocyanurate branching units. According to the studies, the dependence of tensile strength and elongation in branched polyurethanes on the ratio of TDI to TITGMI was established. IR spectroscopic studies found that doxorubicin being in low concentrations in the polymer does not affect changes in the spectra. Comparing the physicomechanical parameters of a polyurethane matrix without doxorubicin with synthesized composite materials, it was found that the introduction of isocyanurate heterocyclic fragments and doxorubicin to the polymer leads to an increase in tensile strength and a decrease in elongation. According to the results of the study of the yield dynamics of the drug, it was found that with an increase in the content of the isocyanurate component in the polymer matrix, the amount of doxorubicin released increases.

Keywords: polyurethanes (PU), doxorubicin (Dox), adipic acid dihydrazide (ADH), output dynamics, implants.

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