2020 (2) 6

https://doi.org/10.15407/polymerj.42.02.125

DEVELOPMENT AND RESEARCH OF POLYMERIC COMPOSITE MATERIALS OF MEDICAL PURPOSE WITH IFOSFAMIDE ON THE BASIS OF POLYURETHANES WITH ISOCIANURATE FRAGMENTS

I.I. Gladyr, 

Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine

ORCID: 0000-0002-6248-2709

G.A. Kozlova,

Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine

ORCID: 0000-0001-8114-4812

L.F. Narazhayko,

Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine

ORCID: 0000-0001-7031-9998

N.A. Galatenko,

Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine,

e-mail: politoks@merlin.net.ua

ORCID: 0000-0002-5961-5750

Polym. J., 2020, 42, no. 2: 125-135.

Section: Medical polymers.

Language: Ukrainian.

Abstract:

Synthesized polyurethane with isocyanurate fragments (PU) based on polyoxypropylene glycol (POPG 1000), TDI (2,4; 2,6: toluene diisocyanate) and 2,4,6-triisocyanate (trishexamethylene) socyanurate (ICC, Tolonate ™ HDT-LV, MM 1200) with a ratio of NCO: OH = 1: 1 in N,N’-dimethylacetamide (DMAA). The tensile strength (σ) of the synthesized PU was 2.6 ± 0.2 MPa; elongation at break (ε) – 58.0 ± 5.5%. The immobilization of Ifosfamide (IFO) on isocyanurate-containing polyurethane was carried out by introducing a solution of IFO in DMAA into the reaction mixture at the rate of 1 mg of IFO per 1 cm² of PU film. The synthesized polymer (PU+IFO) is characterized by σ = (3.4 ± 0.3) MPa; ε = (53.0 ± 6.6)%. It was found that the modification of PU synthesized at a molar ratio of POPG: ICC = 3: 2, Iphosphamide does not lead to significant changes in physical and mechanical properties. According to IR spectroscopy, an IFO is immobilized on a polymer matrix due to intermolecular hydrogen interactions. The biodegradability of isocyanurate-containing polyurethane compositions with IFO was studied by changing the structure and properties under the influence of biological medium 199 (BM 199) for 1 and 6 months. It was found that during incubation in BM 199, samples of PU and PU+IFO are not subject to significant structural changes. The biodegradation of PU+IFO samples after 6 months of incubation is accompanied by a slight increase in the microsegregation of flexible (polyester) and rigid (urethane, isocyanurate) blocks, which leads to an increase in the mobility of the flexible block, respectively, to an increase in the number of hydrogen bonds and, as a result, to an increase in the glass transition temperature. A study of tissue cytotoxicity of isocyanurate-containing polyurethanes with Iphosphamide by tissue culture allows us to conclude that there is no histotoxic effect of IFO in the composition of PU on the growth and development of tissue culture. According to the express toxicology assessment method, composite materials with ifosfamide are biocompatible.

Key words: polyurethanes (PU), isocyanurates, Ifosfamide (IFO), biodegradation, biocompatibility.

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