2020 (3) 6

https://doi.org/10.15407/polymerj.42.03.209
GUANIDINCONTAINING OLIGOMERIC CATIONIC POTONIC IONIC LIQUIDS WITH BIOCIDE ACTIVITY

M.Ya. Vortman,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
E-mail: vmar1962@i.ua
ORCID: 0000-0003-0092-6009
I.M. Furtat,
National University of Kyiv-Mohyla Academy, 2, Grygoriya Skovorody str, Kyiv, 04655, Ukraine
P.V. Vakuliuk,
National University of Kyiv-Mohyla Academy, 2, Grygoriya Skovorody str, Kyiv, 04655, Ukraine
V.N. Lemeshko,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
E-mail: vlem1308@gmail.com
ORCID: 0000-0003-1916-2301
V.V. Shevchenko,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shose, Kyiv, 02160, Ukraine
E-mail: valshevchenko@yandex.ru
ORCID: 0000-0003-2100-4468
Polym. J., 2020, 42, no. 3: 209-217.
Section: Structure and properties.
Language: Russian.

Abstract:

The bactericidal properties of guanidinium-containing oligomeric ionic liquids (OIL) with various counterions in their composition such as chloride, phosphate and formiate have been studied in relation to a number of gram-positive (Micrococcus luteus CCM 169, Corynebacterium ammoniagenes УКМ Ас-732, Сorynebacterium variable УКМ Ас-717, Rhodococcus erythropolis УКМ Ас-741, Staphylococcus aureus CCM 209, Bacillus cereus, Bacillus subtilis CCM 104, Bacillus megaterium ССМ 52) and gram-negative (Enterobacter cloaceas, Serratia marcescens CCM 1257, Escherichia coli, Escherichia coli BE, Escherichia coli HB 101, Pseudomonas aeruginosa CCM 1961, Proteus vulgaris CCM 72, Proteus vulgaris CCM 72, Klebsiella pneumoniae) bacteria, depending on the nature of the counterion. The effect of the counterion on the bactericidal properties of the obtained OIL was studied. The minimum inhibitory concentration of guanidinium-containing oligomeric ionic liquids with various counter-ions with respect to the studied bacterial strains was determined. It has been shown that the highest bactericidal activity and, accordingly, the lowest minimum inhibitory concentration in relation to the studied gram-positive and gram-negative bacteria are possessed by the OIL with chloride ion. A comparative assessment of the bactericidal activity of the studied OIL with the known polyhexamethylene guanidinium chloride, which enjoys the greatest practical demand in terms of biocidal properties, was carried out. The minimum inhibitory concentration for GOIL with chloride ion in relation to most of the bacteria studied is 10 ppm, that is, higher than for chlorhexidine and PHMG and the bactericidal activity is respectively lower. The advantages of the GOIL include the low-temperature synthesis and the presence of functional groups capable of further transformations. The obtained reactive guanidinium OIL, by analogy with PHMG, can be recommended as substances with biocidal, fungicidal properties, the starting component for the production of various polymers and composite materials based on them.

Keywords: guanidinium, ionic liquids, guanidinium ionic liquids, oligomeric ionic liquids, bactericides.

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