2020 (3) 8
https://doi.org/10.15407/polymerj.42.03.226
STUDY OF INCLUSION COMPLEXES OF CARBOXYMETHYLATED-β-CYCLODEXTRIN WITH BIPHONAZOLE AND CLOTRIMAZOL BY THE PYROLYTIC MASS SPECTROMETRY METHOD
V.V. Boyko,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shosse, Kyiv, 02160, Ukraine
ORCID: 0000-0002-5527-0468
L.V. Kobrina,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shosse, Kyiv, 02160, Ukraine
E-mail: kobrina.larisa@gmail.com
ORCID: 0000-0001-6801-0801
V.I. Bortnitsky,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shosse, Kyiv, 02160, Ukraine
ORCID: 0000-0003-4954-6533
D.Yu. Bandurina,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shosse, Kyiv, 02160, Ukraine
ORCID: 0000-0003-1535-2888
S.V. Riabov,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske shosse, Kyiv, 02160, Ukraine
E-mail: imcnasusr@ukr.net
ORCID: 0000-0003-2996-3794
Polym. J., 2020, 42, no. 3: 226-235.
Section: Structure and properties.
Language: Ukrainian.
Abstract:
The purpose of this study is to evaluate the possibility of interaction of the antifungal drugs, like bifonazole and clotrimazole through complexation with carboxymethylated-β-cyclodextrin in aqueous solutions by the pyrolytic mass spectrometry method in order to enhance the solubilisation of that drugs. Analysis of mass-spectra of the initial compounds, their mixtures, and complexes leads us to conclusion that the presence of carboxymethylated-β-cyclodextrin improves the solubilization of bifonazole and clotrimazole as well, due to imidazole groups of drugs being entered into CD’s cavity, meantime, other part of both bifonazole and clotrimazole molecule are located outside the CD’s hydrophobic cavity.
Key words: carboxymethylated β-cyclodextrin, pyrolytic mass spectrometry, inclusion complex, bifonazole, clotrimazole.
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