2016 (1) 10

https://doi.org/10.15407/polymerj.38.01.076

β-Cyclodextrin-containing polymer systems with controlled release of drugs

L.A. Orel, L.V. Kobrina, S.I. Sinelnikov, S.V. Riabov

Institute of Macromolecular Chemistry NAS of Ukraine

48, Kharkivske shose, Kyiv, 02160, Ukraine

Polym. J., 2016, 38, no. 1: 76-80.

Section: Medical polymers.

Language: Ukrainian.

Abstract:

In the work presented, the kinetics of desorption a most ubiquitous drugs (loratadine, diclofenac sodium, metoprolol succinate) from cyclodextrin-containing polymeric matrices is studied and the effect of functionalized β-CD on the rate of desorption is established. It is found, that incorporation of β-CD derivatives into polymer system changes a character of interaction between drug and polymer, allowing to influence the drug release mechanism. It is shown, that increase the degree of cross-linking of the polymer matrix to a certain level leads to enhancing of drugs desorption, but further increasing degree of cross-linking does not influence on drugs release. Incorporating of the β-CD derivatives into polymer matrix results in slowing drugs desorption in 2–4 times. It is of interest for developing of a new drugs-polymer complexes with sustained release. Introduction of cyclodextrin derivatives in polymers can reduce the overall toxicity of drugs and stabilize them during storage.

Key words: polymeric matrices, b-CD derivatives, desorption, drugs.

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