2022 (2) 7

https://doi.org/10.15407/polymerj.44.02.145

INVESTIGATION OF THE ABILITY TO BIODEGRADABILITY OF POLYURETHANE FOAM COMPOSITE MATERIALS WITH ALBUCID AND THE DYNAMICS OF ALBUCID RELEASE IN VITRO

T.V. VISLOHUZOVA,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske Shosse, Kyiv, 02160, Ukraine,
e-mail: rudenchyk@gmail.com
ORCID: 0000-0002-4071-4329
R.A. ROZHNOVA,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske Shosse, Kyiv, 02160, Ukraine,
e-mail: rozhnovarita@gmail.com
ORCID: 0000-0003-3284-3435
N.A. GALATENKO,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske Shosse, Kyiv, 02160, Ukraine,
e-mail: politoks@merlin.net.ua
ORCID: 0000-0002-5961-5750
L.YU. NECHAEVA,
Institute of Macromolecular Chemistry NAS of Ukraine, 48, Kharkivske Shosse, Kyiv, 02160, Ukraine,
e-mail: politoks@merlin.net.ua
ORCID: 0000-0002-9715-5986
Polym. J., 2022, 44, no. 2: 145-154.

Section: Medical polymers.

Language: English.

Abstract:

Studies of biodegradability of polyurethane foam (PUF) composite materials with albucid under the influence of biological medium 199 (BM 199) and saline solution for 2 weeks, 1, 3 and 6 months were conducted. IR spectroscopy, physical-mechanical tests, DSC and TGA before and after incubation in model mediums were investigated. It was found that the influence of BM 199 and saline solution on the structure and properties of composite materials with albucid is similar. According to the results of physical-mechanical studies under the influence of model mediums there are processes of biodegradation which are confirmed by a decrease in adhesive strength after incubation in BM 199 and saline solution. According to IR spectroscopy, biodegradation is accompanied by redistribution of hydrogen bonds of NH groups of the polymer matrix. The results of studies by the DSC method indicate a decrease of Tg and increase of ΔСР of PUF composites with albucid compared to the control, which is associated with increasing of segmental mobility of macromolecules under the influence of model mediums and due to the albucid release from polymer matrix. It was found that PUF and PUF composites with albucid in vitro remain heat-resistant materials, because after incubation in BM 199 and a saline solution there is an increase in T0 and Tmax by the TGA method. Studies of the dynamics of albucid release from the PUF matrix were carried out. It was found that the composite materials are capable to the prolonged release of the drug. The amount of released albucid is 36.0 % on the 60th day of the experiment, which does not exceed the therapeutic dose and has no toxic effects. Therefore, polyurethane foam composite materials with albucid can be proposed as promising materials for use as implants with prolonged action of albucid in ophthalmological surgery.
Keywords: polyurethane foam, composite material, albucid, biological medium 199, saline solution.

REFERENCES
1. McBane J.E., Santerre J.P., Labow R.S. The interaction between hydrolytic and oxidative pathways in macrophage-mediated polyurethane degradation. Journal of Biomedical Materials Research Part A, 2007, 82A, no. 4: 984–994. https://doi.org/10.1002/jbm.a.31263
2. Salmasi S., Nayyer L., Seifalian A.M., Blunn G.W. Nanohydroxyapatite effect on the degradation, osteoconduction and mechanical properties of polymeric bone tissue engineered scaffolds. The Open Orthopaedics Journal, 2016, 10, no. 3: 900–919. https://doi.org/10.2174/1874325001610010900.
3. Hafeman A.E., Zienkiewicz K.J., Zachman A.L., Sung H.-J., Nanney L.B., Davidson J.M., Guelcher S.A. Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds. Biomaterials, 2011, 32, no. 2: 419-429. https://doi.org/10.1016/j.biomaterials.2010.08.108.
4. Visan A.I., Popescu-Pelin G., Socol G. Degradation behavior of polymers used as coating materials for drug delivery — A Basic Review. Polymers (Basel), 2021, 13, no. 8: 1272. https://doi.org/10.3390/polym13081272.
5. Makadia H.K., Siegel S.J. Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Polymers (Basel), 2011, 3, no. 3: 1377–1397. https://doi.org/10.3390/polym3031377.
6. Malanchuk, V.O., Astapenko, O.O., Halatenko, N.A., Rozhnova, R.A. The research of biodegradation of a composite material used in reconstructive and reparative surgery of maxillofacial area. Likars’ka sprava, 2013, no. 6: 83–88.
7. Reza M.S., Quadir M.A., Haider S.S. Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery. Journal of Pharmacy and Pharmaceutical Sciences, 2003, 6, no. 2: 282–291.
8. Varma M.V.S., Kaushal A.M., Garg A., Garg S. Factors Affecting Mechanism and Kinetics of Drug Release from Matrix-Based Oral Controlled Drug Delivery Systems. American Journal of Drug Delivery, 2004, 2, no. 1: 43–57. https://doi.org/10.2165/00137696-200402010-00003.
9. Tiwari S.B., Rajabi-Siahboomi A.R. Extended-Release Oral Drug Delivery Technologies: Monolithic Matrix Systems. In book: Methods in Molecular Biology / Ed.: K.K. Jain. Totowa: Humana Press, 2008, 437: 217–243. https://doi.org/10.1007/978-1-59745-210-6_11.
10. Sivak W.N., Pollack I.F., Petoud S., Zamboni W.C., Zhang J., Beckman E.J. Catalyst-dependent drug loading of LDI–glycerol polyurethane foams leads to differing controlled release profiles. Acta Biomaterialia, 2008, 4, no 5: 1263–1274. https://doi.org/10.1016/j.actbio.2008.01.008.
11. Sivak W.N., Zhang J., Petoud S., Beckman E.J. Simultaneous drug release at different rates from biodegradable polyurethane foams. Acta Biomaterialia, 2009, 5, no. 7: 2398–2408. https://doi.org/10.1016/j.actbio.2009.03.036.
12. Chen W., Carlo C., Devery D., McGrath D. J., McHugh P.E., Kleinsteinberg K., Jockenhoevel S., Hennink W.E., Kok R.J. Fabrication and characterization of gefitinib-releasing polyurethane foam as a coating for drug-eluting stent in the treatment of bronchotracheal cancer. International Journal of Pharmaceutics, 2018, 548, no. 2: 803–811. https://doi.org/10.1016/j.ijpharm.2017.10.026.
13. Vislohuzova T., Rozhnova R., Galatenko N. Development and Research of Polyurethane Foam Composite Materials with Albucid. American Journal of Polymer Science and Technology, 2021, 7, no. 3: 38–43. http://doi.org/10.11648/j.ajpst.20210703.11.
14. Galatenko N.A., Kuliesh D.V., Narazhaiko L.F., Grytsenko V.P., Zakashun T.Iu., Maletskyy A.P., Bigun N.M. Assessing in vitro cytotoxicity and pH of extracts of synthetic polymers made of cross-linked polyurethane composite with immobilized albucid. Journal of Ophthalmology (Ukraine), 2020, no. 4 (495): 56–61. http://doi.org/10.31288/oftalmolzh202045661.
15. Galatenko N.A., Rozhnova R.A., Kuliesh D.V., Vislohuzova T.V., Maletskyy A.P., Bigun N.M. Response of soft tissues and abdominal organs of rabbits and rats to implanting albucid-containing cross-linked polyurethane composite. Journal of Ophthalmology (Ukraine), 2020, no. 6 (497): 30–37. http://doi.org/10.31288/oftalmolzh202063037.
16. ASTM D897-08(2016) Standard Test Method for Tensile Properties of Adhesive Bonds.
17. Mashkovskiy M.D. Lekarstvennyye sredstva. 16 edition, Moscow: Novaja volna, 2012: 1216. ISBN 978-5-7864-0218-7.