2022 (3) 6
https://doi.org/10.15407/polymerj.44.03.222
DEVELOPMENT AND RESEARCH OF COMPOSITE MATERIALS WITH DACARBAZINE OF MEDICAL USING BASED ON POLYURETHANE FOAM UREAS
V.D. DENISENKO,
Institute of Macromolecular Chemistry NAS of Ukraine, 48 Kharkivske shose, Kyiv, 02155, Ukraine
e-mail: politoks@merlin.net.ua
ORCID: 0000-0003-3675-769X
R.A. ROZHNOVA,
Institute of Macromolecular Chemistry NAS of Ukraine, 48 Kharkivske shose, Kyiv, 02155, Ukraine
e-mail: rozhnovarita@gmail.com
ORCID: 0000-0002-5961-5750
N.A. GALATENKO,
Institute of Macromolecular Chemistry NAS of Ukraine, 48 Kharkivske shose, Kyiv, 02155, Ukraine
e-mail: galatenkonataliia@gmail.com
ORCID: 0000-0003-3284-3435
L.YU. NECHAEVA,
Institute of Macromolecular Chemistry NAS of Ukraine, 48 Kharkivske shose, Kyiv, 02155, Ukraine
e-mail: l.ne4aeva@gmail.com
ORCID: 0000-0002-9715-5986
Polym. J., 2022, 44, no. 3: 222-230.
Section: Medical polymers.
Language: Ukrainian.
Abstract:
Developed a new composite material with Dacarbazine based on polyurethane foam (PPUS) The content of the drug substance Dacarbazine (DAC) in the composition was 0.5 wt. % and 1.0 wt.%. PPUS was obtained on the basis of a mixture of oligourethane diisocyanates (OUDIC) synthesized on the basis of 2,4-;2,6-toluene diisocyanate and polyoxypropylene glycols (POPG) MM 1002 and MM 2002 in a ratio of 1:1. Comparative physical and mechanical tests were performed. According to the obtained results, PPUS with DAC in the amount of 1 wt.% have physical and mechanical parameters (σ = 7.8, MPa, ε = 100% and σadhesion = 4.5 MPa), that will meet the requirements for replacement implants for ophthalmology. According to the results of IR spectroscopy, the possibility of chemical immobilization of Dacarbazine on the selected polymeric carrier was established. The thermophysical properties of the synthesized PPUS with Dacarbazine by DSC and TGA methods were studied. It was found that the glass transition temperature (Tg) is practically independent of the content of DAC. Tg PPUS with 0.5 wt.% DAC – (minus) 49.70 °C, Tg PPUS with 1.0 wt.% DAC – (minus) 50.09 °C. According to TGA, the obtained materials are characterized by the same heat resistance characteristics and practically do not depend on the content of DAC. The onset temperature of thermal decomposition (To) is in the range (290,96–298,61) °C and is accompanied by a slight weight loss (0.02–0.04 %). The temperature of maximum decomposition rate (Tmax ) is in the range (331.93–333.95) °C. According to the results of the dynamics of Dacarbazine release study from PPUS samples with a DAC content in the composition of 0.5 and 1.0 wt. % found that the composition of PPUS with a content of DAC 1 wt. % have a higher percentage of medicine, which on day 14 is ~ 64 %. The developed PPUS with Dacarbazine are promising materials for use as implants for ophthalmological surgery.
Key words: polyurethane foam urea, composite material, Dacarbazine, drug release, implant.
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Received 23.05.2022