2015 (4) 13
https://doi.org/10.15407/polymerj.37.04.416
Nanosized ferrohydrogels based on N-isopropilacrylamide for controlled drug resease
Yu. Samchenko1, V. Konovalova2, S. Kryklua1, N. Pasmurceva1
1Institute of Biocolloid Chemistry NAS of Ukraine
42, Vernadsky av., Kyiv, 03680, Ukraine, yu1sam@yahoo.com
2National University of Kiev-Mohyla Academy
2, Skovorody str., Kyiv, 04655, Ukraine, vita@ukma.kiev.ua
Polym. J., 2015, 37, no. 4: 416-422.
Section: Medical polymers.
Language: Ukrainian.
Abstract:
Development of nanosized transport drugs to ensure their targeted delivery to target organs and release with controlled speed urgent task of polymer chemistry, nanotechnology and pharmaceuticals. In the paper nanosized hydrogels and ferrogels were synthesized by suspension polymerization of N-izopropylacrylamide and methylenbisacrylamide. The method of scanning electron microscopy and dynamic light scattering demonstrated that nanogel size varies in the range 100–200 nm. Obtained nanogels characterized thermal, pH and magneto-sensitive properties. Hydrogel is characterized by a clear phase transition when heated above the temperature of 32 °C. it has been shown the possibility of providing hydrogels magneto-sensitive properties by the incorporation of previously synthesized nanoparticles of magnetite with an average size of about 15 nm. Obtained nanogels could be applied for targeted localization near their target organs, allowing use of these delivery systems of medicines in a medical hyperthermia.
Key words: nanohydrogel, nanoferrogels thermo sensitivity, pH-responsive, N-isopropilacrylamide.
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